About this Research Topic
Cerebral cavernous malformations (CCMs) are complex vascular lesions that can cause significant neurological morbidity through bleeding, seizures, and focal deficits. Over the past decade, there have been significant advancements in our understanding of the pathogenesis, diagnosis, and management of these lesions.
We invite submissions of Original Research Articles, Reviews, Methods, and Perspectives that address the following topics:
1. Diagnostic Advancements:
• Emerging neuroimaging techniques for the detection and characterization of CCMs
• Biomarkers and genetic testing for CCM diagnosis and risk stratification
2. Treatment Modalities:
• Surgical management, including patient selection, technical advancements, and intraoperative neurophysiological monitoring (IONM)
• The role of stereotactic radiosurgery and its outcomes
• Novel therapeutic approaches targeting the underlying molecular pathways
3. Pathogenesis and Molecular Mechanisms:
• Genetic and signaling pathways involved in CCM formation and progression
• Cellular and molecular mechanisms underlying CCM-associated vascular dysfunction and hemorrhage
4. Translational and Clinical Research:
• Animal models and in vitro studies providing insights into CCM pathogenesis
• Clinical studies evaluating the impact of CCM on patient outcomes
• Multidisciplinary approaches to CCM management and care
We welcome submissions from clinicians, researchers, and trainees in the fields of neurosurgery, neurology, neuroradiology, and molecular biology. Accepted articles will be published in Frontiers in Neurology, which is dedicated to advancing the understanding and treatment of cerebrovascular disorders.
We look forward to receiving your contributions and to furthering the scientific discourse on the latest advancements in the field of cerebral cavernous malformations.
We invite submissions of Original Research Articles, Reviews, Methods, and Perspectives that address the following topics:
1. Diagnostic Advancements:
• Emerging neuroimaging techniques for the detection and characterization of CCMs
• Biomarkers and genetic testing for CCM diagnosis and risk stratification
2. Treatment Modalities:
• Surgical management, including patient selection, technical advancements, and intraoperative neurophysiological monitoring (IONM)
• The role of stereotactic radiosurgery and its outcomes
• Novel therapeutic approaches targeting the underlying molecular pathways
3. Pathogenesis and Molecular Mechanisms:
• Genetic and signaling pathways involved in CCM formation and progression
• Cellular and molecular mechanisms underlying CCM-associated vascular dysfunction and hemorrhage
4. Translational and Clinical Research:
• Animal models and in vitro studies providing insights into CCM pathogenesis
• Clinical studies evaluating the impact of CCM on patient outcomes
• Multidisciplinary approaches to CCM management and care
We welcome submissions from clinicians, researchers, and trainees in the fields of neurosurgery, neurology, neuroradiology, and molecular biology. Accepted articles will be published in Frontiers in Neurology, which is dedicated to advancing the understanding and treatment of cerebrovascular disorders.
We look forward to receiving your contributions and to furthering the scientific discourse on the latest advancements in the field of cerebral cavernous malformations.
Keywords: cavernous malformations, neuroimaging, Biomarkers, Surgical management, IONM, molecular mechanisms
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
