Frontiers | Proteostasis disruption in neurodegenerative disorders: Mechanisms and treatment strategies

Proteostasis disruption in neurodegenerative disorders: Mechanisms and treatment strategies

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ORIGINAL RESEARCH

Published on 20 Feb 2025

Multi-omics-based phenotyping of AFG3L2-mutant lymphoblasts determines key factors of a pathophysiological interplay between mitochondrial vulnerability and neurodegeneration in spastic ataxia type 5

Menekse Oeztuerk
Diran Herebian
Kale Dipali
Andreas Hentschel
Nina Rademacher
Florian Kraft
Rita Horvath
Felix Distelmaier
Sven G. Meuth
2 more
Andreas Roos

doi 10.3389/fnmol.2025.1548255

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REVIEW

Published on 23 Oct 2024

Liquid–liquid phase separation and conformational strains of α-Synuclein: implications for Parkinson’s disease pathogenesis

Eva D. Ruiz-Ortega
Anna Wilkaniec
Agata Adamczyk

doi 10.3389/fnmol.2024.1494218

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Frontiers in Molecular Neuroscience

Frontiers in Molecular Neuroscience

Brain Disease Mechanisms

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