About this Research Topic
Gene editing, particularly with the CRISPR-Cas9 system, has become a cornerstone in the evolution of immune cell therapies, offering a means to enhance T cell specificity, counteract the immunosuppressive tumor microenvironment, and improve treatment safety and efficacy. By engineering T cells to recognize tumor-associated antigens more accurately and overcome intrinsic limitations, gene editing paves the way for personalized treatments that could be more effective against cancer. Despite the promise, challenges such as off-target effects, manufacturing scalability, and regulatory compliance must be addressed to realize the full therapeutic potential of this technology.
Recent advances have introduced more precise editing tools, successful clinical applications of CAR-T therapies, and innovative manufacturing processes, all of which are pushing the field towards safer and more effective personalized treatments. As the development of gene editing in immune cell therapy has recently seen a surge in interest, it is crucial to summarize the existing challenges and reveal the current research progress in this dynamic field.
The aim of the current Research Topic is to cover promising, recent, and novel research trends in the Gene editing in immune cell therapy. Areas to be covered in this Research Topic may include, but are not limited to:
· Precision Gene Editing Techniques
· Enhancing T Cell Therapies
· Overcoming Tumor Heterogeneity
· Tumor Microenvironment Modulation
· Immune Cell Persistence and Memory
· Combination Therapies
Recent advances have introduced more precise editing tools, successful clinical applications of CAR-T therapies, and innovative manufacturing processes, all of which are pushing the field towards safer and more effective personalized treatments. As the development of gene editing in immune cell therapy has recently seen a surge in interest, it is crucial to summarize the existing challenges and reveal the current research progress in this dynamic field.
The aim of the current Research Topic is to cover promising, recent, and novel research trends in the Gene editing in immune cell therapy. Areas to be covered in this Research Topic may include, but are not limited to:
· Precision Gene Editing Techniques
· Enhancing T Cell Therapies
· Overcoming Tumor Heterogeneity
· Tumor Microenvironment Modulation
· Immune Cell Persistence and Memory
· Combination Therapies
Keywords: Gene editing, immune cell therapy, CRISPR-Cas9, T cell engineering, cancer treatment
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