Advanced Optical Technologies for Biosensing and Analysis

Optical technologies offer numerous advantages over conventional methods, including high sensitivity, noninvasive fast analysis, and superior spatial resolution. Due to their structural tailorability, optical probes exhibit excellent cell permeability and adaptability to a wide range of targeted biomarkers. With the continual advancement of optical probes, imaging technologies such as fluorescence imaging, chemiluminescence imaging, bioluminescence imaging, photoacoustic imaging, fluorescence lifetime imaging, and phosphorescence lifetime imaging have become powerful tools for real-time monitoring and imaging of biomarkers in living systems. These unique properties make optical probes particularly promising and efficient tools for biosensing and analysis. Despite the significant development of optical imaging technology over the past decade, there remains a lack of established optical measuring methods in clinical diagnosis. This gap underscores the need for further research to translate these advanced technologies into clinical practice, thereby enhancing disease diagnosis and treatment.

This research topic aims to highlight advances in biosensing and disease-related analysis through the development of optical probes, including fluorescent, chemiluminescent, bioluminescent, phosphorescent, and photoacoustic probes, and their imaging applications. The objective is to improve research on disease pathogenesis, diagnosis, and therapy, and to introduce new prospective diagnostic and therapeutic agents and methods, thereby expanding the application of optical imaging technology in clinical practice. The resulting research achievements will provide timely updates in this rapidly evolving field.

To gather further insights into the application and development of advanced optical technologies for biosensing and analysis, we welcome articles addressing, but not limited to, the following themes:

• Development and application of various optical tools (including fluorescent, chemiluminescent, bioluminescent, phosphorescent, and photoacoustic) for biosensing and imaging.
• Application of various optical tools (including fluorescent, chemiluminescent, bioluminescent, phosphorescent, and photoacoustic) in biological analysis.
• Investigating disease mechanisms using the aforementioned optical technologies.
• Introduction of new optical technologies with diagnostic and therapeutic functions for related diseases.

Keywords: Optical Technologies, Biological imaging, Biosensing, Biosensor, Disease diagnosis and therapy

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.