About this Research Topic
Obesity, Type 2 Diabetes Mellitus, and Metabolic Syndrome represent a triad of interrelated metabolic disorders that have reached epidemic proportions globally, contributing significantly to morbidity and mortality rates. The increasing prevalence of these conditions underscores the urgent need for a deeper understanding of their pathophysiological mechanisms and the development of effective therapeutic strategies.
Obesity is characterized by excessive adipose tissue accumulation, which disrupts normal metabolic processes and is a primary risk factor for the development of Type 2 Diabetes and Metabolic Syndrome. Metabolic Syndrome comprises a cluster of metabolic abnormalities, including central obesity, hyperglycemia, dyslipidemia, and hypertension, which collectively heighten the risk of cardiovascular disease and other complications.
The pathogenesis of these disorders is multifaceted, involving intricate interactions between genetic predispositions, environmental influences, and lifestyle factors. Central to their development are dysregulations in cellular and molecular pathways, particularly those governing energy homeostasis, insulin signaling, and inflammatory responses. Adipose tissue, beyond its role in energy storage, functions as an active endocrine organ, secreting various adipokines that influence metabolic processes and systemic inflammation.
Advancements in cellular and molecular biology have illuminated several key mechanisms underlying these metabolic disorders. Recent research has identified novel biomarkers and elucidated the roles of specific inflammatory pathways, metabolic regulators, and genetic factors. These discoveries have opened new avenues for therapeutic interventions aimed at restoring metabolic balance and mitigating disease progression.
This special edition of Frontiers in Cell and Developmental Biology seeks to collate and disseminate the latest research findings on the cellular and molecular underpinnings of Obesity, Type 2 Diabetes, and Metabolic Syndrome. The focus will be on groundbreaking studies that provide insights into the pathophysiology of these conditions and propose innovative therapeutic approaches. By integrating these diverse perspectives, this edition aims to enhance our scientific understanding and foster the development of novel clinical strategies to combat these pervasive metabolic disorders.
The primary goal of this special edition of Frontiers in Cell and Developmental Biology is to advance the scientific understanding of the cellular and molecular mechanisms underlying Obesity, Type 2 Diabetes, and Metabolic Syndrome. By gathering cutting-edge research and novel insights, this edition aims to:
-Illuminate Pathophysiological Mechanisms: Enhance the comprehension of the complex cellular and molecular pathways involved in the development and progression of Obesity, Type 2 Diabetes, and Metabolic Syndrome. This includes a focus on adipose tissue function, insulin signaling, energy metabolism, and inflammatory processes.
-Identify Novel Biomarkers: Highlight new biomarkers that can serve as diagnostic tools or therapeutic targets, thereby improving early detection and personalized treatment strategies for these metabolic disorders.
This special edition of Frontiers in Cell and Developmental Biology invites submissions that explore the cellular and molecular mechanisms underlying Obesity, Type 2 Diabetes, and Metabolic Syndrome. We welcome original research articles, reviews, and perspectives that address key themes such as:
-Pathophysiological Mechanisms: Studies on the molecular pathways and cellular processes involved in energy metabolism, insulin resistance, and adipose tissue function.
-Inflammatory Pathways: Research on the role of inflammation in the development and progression of metabolic disorders.
-Biomarkers and Diagnostics: Identification and validation of novel biomarkers for early detection and monitoring of disease progression.
-Therapeutic Strategies: Innovative approaches for the prevention and treatment of these conditions, including pharmacological interventions, lifestyle modifications, and gene therapies.
-Genetic and Epigenetic Factors: Insights into the genetic and epigenetic influences on susceptibility and disease progression.
We seek manuscripts that provide robust data, novel insights, and have potential translational value to bridge the gap between basic research and clinical practice. Submissions should adhere to the journal's guidelines and aim to contribute to the advancement of knowledge in this critical field.
Obesity is characterized by excessive adipose tissue accumulation, which disrupts normal metabolic processes and is a primary risk factor for the development of Type 2 Diabetes and Metabolic Syndrome. Metabolic Syndrome comprises a cluster of metabolic abnormalities, including central obesity, hyperglycemia, dyslipidemia, and hypertension, which collectively heighten the risk of cardiovascular disease and other complications.
The pathogenesis of these disorders is multifaceted, involving intricate interactions between genetic predispositions, environmental influences, and lifestyle factors. Central to their development are dysregulations in cellular and molecular pathways, particularly those governing energy homeostasis, insulin signaling, and inflammatory responses. Adipose tissue, beyond its role in energy storage, functions as an active endocrine organ, secreting various adipokines that influence metabolic processes and systemic inflammation.
Advancements in cellular and molecular biology have illuminated several key mechanisms underlying these metabolic disorders. Recent research has identified novel biomarkers and elucidated the roles of specific inflammatory pathways, metabolic regulators, and genetic factors. These discoveries have opened new avenues for therapeutic interventions aimed at restoring metabolic balance and mitigating disease progression.
This special edition of Frontiers in Cell and Developmental Biology seeks to collate and disseminate the latest research findings on the cellular and molecular underpinnings of Obesity, Type 2 Diabetes, and Metabolic Syndrome. The focus will be on groundbreaking studies that provide insights into the pathophysiology of these conditions and propose innovative therapeutic approaches. By integrating these diverse perspectives, this edition aims to enhance our scientific understanding and foster the development of novel clinical strategies to combat these pervasive metabolic disorders.
The primary goal of this special edition of Frontiers in Cell and Developmental Biology is to advance the scientific understanding of the cellular and molecular mechanisms underlying Obesity, Type 2 Diabetes, and Metabolic Syndrome. By gathering cutting-edge research and novel insights, this edition aims to:
-Illuminate Pathophysiological Mechanisms: Enhance the comprehension of the complex cellular and molecular pathways involved in the development and progression of Obesity, Type 2 Diabetes, and Metabolic Syndrome. This includes a focus on adipose tissue function, insulin signaling, energy metabolism, and inflammatory processes.
-Identify Novel Biomarkers: Highlight new biomarkers that can serve as diagnostic tools or therapeutic targets, thereby improving early detection and personalized treatment strategies for these metabolic disorders.
This special edition of Frontiers in Cell and Developmental Biology invites submissions that explore the cellular and molecular mechanisms underlying Obesity, Type 2 Diabetes, and Metabolic Syndrome. We welcome original research articles, reviews, and perspectives that address key themes such as:
-Pathophysiological Mechanisms: Studies on the molecular pathways and cellular processes involved in energy metabolism, insulin resistance, and adipose tissue function.
-Inflammatory Pathways: Research on the role of inflammation in the development and progression of metabolic disorders.
-Biomarkers and Diagnostics: Identification and validation of novel biomarkers for early detection and monitoring of disease progression.
-Therapeutic Strategies: Innovative approaches for the prevention and treatment of these conditions, including pharmacological interventions, lifestyle modifications, and gene therapies.
-Genetic and Epigenetic Factors: Insights into the genetic and epigenetic influences on susceptibility and disease progression.
We seek manuscripts that provide robust data, novel insights, and have potential translational value to bridge the gap between basic research and clinical practice. Submissions should adhere to the journal's guidelines and aim to contribute to the advancement of knowledge in this critical field.
Keywords: Obesity, Type 2 Diabetes, Metabolic Syndrome, Cellular Mechanisms, Pathophysiology, Therapeutic Strategies, Energy Metabolism, Insulin Resistance, Adipose Tissue
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
