Mitochondrial Pathophysiology in Cardiomyopathy and Cardiac Senescence

Understanding mitochondrial mechanisms is crucial for elucidating pathophysiological responses and developing clinical therapies in heart diseases. Significant progress has been made in identifying mitochondrial signals and performance involved in various cardiac conditions. However, a comprehensive understanding of the mitochondrial mechanisms underlying conditions like cardiomyopathy and cardiac senescence remains incomplete. This Research Topic aims to deepen our understanding of the complexities of mitochondrial pathophysiology in cardiomyopathy and the senescent heart, and to explore the potential of targeting mitochondria in translational physiology and clinical remedy.

We welcome original research articles and reviews that explore a broad array of themes related to this research area. Topics of interest include, but are not limited to:

• Clinical characteristics of cardiac mitochondrial bioenergetics in heart disease and metabolic diseases, including diabetic vasculopathy-caused cardiovascular and peripheral arterial diseases
• Clinical and molecular aspects of inflammation-mitochondria axis in heart disease and metabolic diseases
• Translational potential of mitochondria transplantation in heart disease
• Targeting mitochondrial epigenetics in cardiomyopathy/heart failure and senescence
• Mitochondrial regulation in cardiac regeneration
• Interaction of myocardial mitochondria with exosomes and extracellular vesicles
• Multiomics approaches and novel technologies for assessing myocardial mitochondrial responses

Contributions should focus on all levels of investigation, from subcellular and cellular studies to whole-organ analyses.

Keywords: mitochondria, cardiomyopathy, cardiac senescence, pathophysiology, bioenergetics, multiomics approaches, inflammation, extracellular vesicles, epigenetics

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.