About this Research Topic

Background

Infections by multidrug resistant organisms (MDROs) are a global health threat with a worrying increasing trend. In fragile host, colonization and infection by MDROs pose a major clinical management challenge. Mainly carbapenem resistant Enterobacterales (CRE) and difficult to treat non fermentative Gram-negative bacteria (DTR-NFGN) are a serious thematic in fragile subjects such as elderly transplanted or hematologic patients and any other type of immunocompromised hosts.

Continuous analyses of epidemiology, microbiology, new therapeutic and prophylactic strategies are essential contributions to prevent colonization, to reduce spreading and to improve management of infections by MDROs in these patients’ categories. This Research Topic focuses on the emerging Gram negative MDROs, their resistance mechanisms, their epidemiology and new therapeutics in fragile hosts.

This Research Topic covers, but is not limited to, the following subtopics:

1. Epidemiology of different molecular mechanism of CRE and DTR-NFGN (Stenotrophomonas maltophilia, Acinetobacter baumannii and Pseudomonas aeruginosa) in solid organ transplant recipients, hematologic patients, elderly, people living with HIV (PLWH).

2. New antibiotic strategy to manage clinical infections by CRE and DTR-NFGN in solid organ transplant recipients, hematologic patients, elderly, other immunocompromised hosts based on different molecular resistance mechanisms.

3. Prevalence of different genotypes of Gram-negative MDROs and their possible interaction with saprophytic microbiota in colonized solid organ transplant recipients, hematologic patients, elderly, other immunocompromised hosts.

4. Prevalence of different genotypes of Gram negative MDROs and outcomes of related infections in solid organ transplant recipients, hematologic patients, elderly, other immunocompromised hosts.

We welcome the following article types:

1. For the Antimicrobials, Resistance and Chemotherapy section: Methods, Mini Review, Original Research, Perspective, Review, Systematic Review.

2. For the Clinical infectious Diseases section: Methods, Mini Review, Original Research, Perspective, Review.

3. For the Hematologic Malignancies section: Brief Research Report, Clinical Trial, Mini Review, Original Research, Review, Systematic Review.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Multiresistance, Gram negative, Immunocompromised host, Elderly, Transplanted host, Hematologic host, Therapy, Epidemiology, Resistance mechanism

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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