Muscle atrophy, also known as muscle wasting, and sarcopenia, which refers to the age-related decline in muscle mass and function, are characterized by significant muscle mass reduction and dysfunction. These conditions result in a lower quality of life and an increased risk of morbidity and mortality. Various factors contribute to muscle loss, including aging (leading to sarcopenia), chronic diseases (such as heart failure, renal failure, chronic obstructive pulmonary disease, and cancer cachexia), inactivity (immobilization), and denervation.
The molecular mechanisms underlying muscle atrophy and sarcopenia are complex and multifaceted. Mechanistically, several pathophysiological processes, including oxidative stress and inflammation, activate various signal transduction pathways such as the ubiquitin-proteasome system, autophagy-lysosome system, and mTOR. Although exercise is widely recognized as an effective countermeasure, it has limited applicability for patients with decreased mobility. With the global aging population, muscle atrophy and sarcopenia pose significant economic and social burdens. There is an urgent need for effective treatments for these conditions, necessitating new insights into their mechanisms and therapeutic strategies.
This Research Topic aims at discussing the pathogenesis of muscle atrophy/sarcopenia and developing effective therapeutic strategies. Although excessive protein degradation was considered as the main reason of muscle atrophy and sarcopenia, the effective prevention and treatment strategies are still largely limited. Hence, the spotlight of this Research Topic is on the cellular and molecular mechanisms of muscle atrophy and sarcopenia, as well as fueling innovative design proposals for developing novel therapies.
This research topic will encompass a diversified range of scholarly compositions including research articles, (mini)reviews, theoretical propositions, commentaries, and perspectives within this field. Potential topics include but are not limited to the following:
● Emerging cellular and molecular mechanisms contributing to muscle atrophy and sarcopenia
● Insights into cellular and molecular mechanisms driving muscle repair
● Identification and exploration of biomarkers associated with muscle atrophy and sarcopenia
● Innovation in methods and pharmacological interventions for muscle atrophy and sarcopenia treatment
Keywords:
muscle atrophy, muscle wasting, pathogenesis, therapeutics, biomarkers
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Muscle atrophy, also known as muscle wasting, and sarcopenia, which refers to the age-related decline in muscle mass and function, are characterized by significant muscle mass reduction and dysfunction. These conditions result in a lower quality of life and an increased risk of morbidity and mortality. Various factors contribute to muscle loss, including aging (leading to sarcopenia), chronic diseases (such as heart failure, renal failure, chronic obstructive pulmonary disease, and cancer cachexia), inactivity (immobilization), and denervation.
The molecular mechanisms underlying muscle atrophy and sarcopenia are complex and multifaceted. Mechanistically, several pathophysiological processes, including oxidative stress and inflammation, activate various signal transduction pathways such as the ubiquitin-proteasome system, autophagy-lysosome system, and mTOR. Although exercise is widely recognized as an effective countermeasure, it has limited applicability for patients with decreased mobility. With the global aging population, muscle atrophy and sarcopenia pose significant economic and social burdens. There is an urgent need for effective treatments for these conditions, necessitating new insights into their mechanisms and therapeutic strategies.
This Research Topic aims at discussing the pathogenesis of muscle atrophy/sarcopenia and developing effective therapeutic strategies. Although excessive protein degradation was considered as the main reason of muscle atrophy and sarcopenia, the effective prevention and treatment strategies are still largely limited. Hence, the spotlight of this Research Topic is on the cellular and molecular mechanisms of muscle atrophy and sarcopenia, as well as fueling innovative design proposals for developing novel therapies.
This research topic will encompass a diversified range of scholarly compositions including research articles, (mini)reviews, theoretical propositions, commentaries, and perspectives within this field. Potential topics include but are not limited to the following:
● Emerging cellular and molecular mechanisms contributing to muscle atrophy and sarcopenia
● Insights into cellular and molecular mechanisms driving muscle repair
● Identification and exploration of biomarkers associated with muscle atrophy and sarcopenia
● Innovation in methods and pharmacological interventions for muscle atrophy and sarcopenia treatment
Keywords:
muscle atrophy, muscle wasting, pathogenesis, therapeutics, biomarkers
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.