Intestinal microenvironment and autoimmune diseases

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About this Research Topic

Submission deadlines

  1. Manuscript Submission Deadline 28 March 2025

  2. This Research Topic is still accepting articles.

Background

The field of intestinal microenvironment and autoimmune diseases is gaining significant attention due to its potential role in the pathogenesis of these complex conditions. Autoimmune diseases are characterized by the immune system mistakenly attacking the body's own tissues, and while some have identified autoantigens, the precise causes remain elusive in many cases. The intestine, housing 60-70% of the body's peripheral immune cells, serves as a critical site for interactions with a vast array of microorganisms. These interactions, along with potential damage to the intestinal barrier, may facilitate microbial translocation, contributing to autoimmune diseases such as rheumatoid arthritis and retinitis pigmentosa. Despite ongoing research, the specific intestinal pathogenic factors and pathways leading to these diseases are not fully understood. Current studies are beginning to unravel these complexities, yet there remains a significant gap in understanding the precise mechanisms and the role of the gut microenvironment in the comorbidities of different autoimmune diseases.

This research topic aims to identify intestinal-specific pathogenic factors and mechanisms involved in autoimmune diseases. It seeks to explore the differences and similarities in the gut microenvironment across various autoimmune conditions, with the objective of elucidating the intestinal mechanisms underlying comorbidities. Additionally, the research will investigate the impact of diet and other lifestyle activities on the regulation of the intestinal microenvironment and their subsequent effects on autoimmune diseases. By addressing these aims, the research hopes to provide a clearer understanding of the intestinal factors contributing to autoimmune pathogenesis and potential therapeutic interventions.

To gather further insights into the intestinal microenvironment's role in autoimmune diseases, we welcome articles addressing, but not limited to, the following themes:
- Changes in the intestinal microenvironment, including microbial metabolites, in autoimmune diseases
- Mechanisms of the intestinal microenvironment in the pathogenesis of autoimmune diseases
- Associations between the intestinal microenvironment and the clinical characteristics of autoimmune diseases
- Associations between the intestinal microenvironment and complications of autoimmune diseases
- Influence or regulation of diet on the intestinal microenvironment and autoimmune diseases
- Treatment of autoimmune diseases through regulation of the intestinal microenvironment

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  • Methods
  • Mini Review

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Keywords: autoimmune diseases

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