About this Research Topic
Biofilm and quorum sensing significantly increase microbial pathogenicity and resilience in life-threatening human diseases. Biofilms, bacterial communities within an extracellular matrix, shield bacteria from the host immune system and antibiotics, leading to chronic and challenging infections. Quorum sensing, a mechanism regulating biofilm formation by coordinating gene expression based on population density, enhances biofilm production, virulence factors, and antibiotic resistance.
Biofilm-forming bacteria are often implicated in chronic wounds, urinary tract infections, and lung infections, resulting in higher morbidity, prolonged treatment times, and increased costs. Understanding quorum sensing circuits is crucial for developing therapeutic strategies to combat biofilm-associated infections.
This research topic aims to combine cutting-edge studies that utilize integrative multi-omics approaches encompassing genomics, transcriptomics, proteomics, metabolomics, and computational biology to decipher the complex mechanisms underlying biofilm resilience. Understanding these intricate networks allows us to develop novel and effective biofilm disruption and control strategies.
This topic invites manuscripts that provide new insights into biofilm biology, innovative disruption methods, and applications of advanced technologies to manage biofilms in diverse environments with a particular focus on biofilm resilience:
• Genomic, Transcriptomics, Proteomic, and metabolomic insights into Biofilm Resilience: Essential genes, regulatory networks, transcriptome profiling of gene expression and non-coding RNA roles, proteomic and metabolomic studies revealing resilience factors and crucial metabolic pathways associated with biofilm characteristics, and the genetic foundation of biofilm formation and persistence
• Structural biology approaches to study and control biofilm formation: We encourage papers from structural biology, including high-resolution imaging, analysis of proteins and biofilm architecture, computational modeling of regulatory networks, and simulation studies predicting biofilm behavior.
• Computational and Systems Biology of Biofilms: Innovative strategies on the effects of the environment and the ecological interactions within biofilm communities are of interest, as is the development of novel antimicrobial drugs, quorum sensing inhibitors, and biofilm-resistant materials.
• Synthetic Biology and Genetic Engineering: Research focusing on integrative synthetic biology techniques and genetic engineering approaches like CRISPR and gene knock-out strategies to improve biofilm control.
Biofilm-forming bacteria are often implicated in chronic wounds, urinary tract infections, and lung infections, resulting in higher morbidity, prolonged treatment times, and increased costs. Understanding quorum sensing circuits is crucial for developing therapeutic strategies to combat biofilm-associated infections.
This research topic aims to combine cutting-edge studies that utilize integrative multi-omics approaches encompassing genomics, transcriptomics, proteomics, metabolomics, and computational biology to decipher the complex mechanisms underlying biofilm resilience. Understanding these intricate networks allows us to develop novel and effective biofilm disruption and control strategies.
This topic invites manuscripts that provide new insights into biofilm biology, innovative disruption methods, and applications of advanced technologies to manage biofilms in diverse environments with a particular focus on biofilm resilience:
• Genomic, Transcriptomics, Proteomic, and metabolomic insights into Biofilm Resilience: Essential genes, regulatory networks, transcriptome profiling of gene expression and non-coding RNA roles, proteomic and metabolomic studies revealing resilience factors and crucial metabolic pathways associated with biofilm characteristics, and the genetic foundation of biofilm formation and persistence
• Structural biology approaches to study and control biofilm formation: We encourage papers from structural biology, including high-resolution imaging, analysis of proteins and biofilm architecture, computational modeling of regulatory networks, and simulation studies predicting biofilm behavior.
• Computational and Systems Biology of Biofilms: Innovative strategies on the effects of the environment and the ecological interactions within biofilm communities are of interest, as is the development of novel antimicrobial drugs, quorum sensing inhibitors, and biofilm-resistant materials.
• Synthetic Biology and Genetic Engineering: Research focusing on integrative synthetic biology techniques and genetic engineering approaches like CRISPR and gene knock-out strategies to improve biofilm control.
Keywords: Biofilm Resilience, Quorum Sensing, Multi-Omics Approaches, Antimicrobial Strategies, Structural Biology, Synthetic Biology
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
