About this Research Topic
Oral potentially malignant disorders (OPMD) are prevalent oral and maxillofacial diseases with the potential to develop into oral cancer, which represents a significant threat to the physical and mental health of patients. However, the current state of research on OPMD remains inadequate, and there is a dearth of efficacious clinical interventions for malignant transformation. It is anticipated that the article collection focusing on advances and innovative discoveries in OPMD will facilitate a deeper comprehension of the disease from bench to clinic, thereby promoting precision medicine-based clinical management.
Oral potentially malignant disorders (OPMD) comprise a group of lesions that compromise the normal oral mucosa and increase the risk of developing oral squamous cell carcinoma (OSCC). It is imperative to identify the risk factors that contribute to malignant transformation, to gain insight into the involved mechanisms and to implement risk stratification in order to facilitate the implementation of early intervention strategies for the management of OPMD. However, our understanding of the natural history of OPMD has not been fully elucidated, and the precise strategies based on the integration of various predictive markers have yet to be validated in clinical trials. It is therefore essential to gain a deeper understanding of the complex factors involved in the malignant transformation of OPMD, in order to develop highly effective prevention and intervention strategies.
The Research Topic concentrates on the advances and innovative discoveries in the field of OPMD. They (including Original Research, Review, etc.) encompass, but are not limited to, the following areas of study:
• Pathogenesis and malignant transformation mechanisms of OPMD.
• Genomics, transcriptomics, microbiomics, metabolomics and other multi-omics studies on OPMD.
• Advances in the immune microenvironment and immunoregulation of OPMD.
• Application of artificial intelligence in OPMD.
• Well-designed clinical trials and cohort studies on OPMD.
Oral potentially malignant disorders (OPMD) comprise a group of lesions that compromise the normal oral mucosa and increase the risk of developing oral squamous cell carcinoma (OSCC). It is imperative to identify the risk factors that contribute to malignant transformation, to gain insight into the involved mechanisms and to implement risk stratification in order to facilitate the implementation of early intervention strategies for the management of OPMD. However, our understanding of the natural history of OPMD has not been fully elucidated, and the precise strategies based on the integration of various predictive markers have yet to be validated in clinical trials. It is therefore essential to gain a deeper understanding of the complex factors involved in the malignant transformation of OPMD, in order to develop highly effective prevention and intervention strategies.
The Research Topic concentrates on the advances and innovative discoveries in the field of OPMD. They (including Original Research, Review, etc.) encompass, but are not limited to, the following areas of study:
• Pathogenesis and malignant transformation mechanisms of OPMD.
• Genomics, transcriptomics, microbiomics, metabolomics and other multi-omics studies on OPMD.
• Advances in the immune microenvironment and immunoregulation of OPMD.
• Application of artificial intelligence in OPMD.
• Well-designed clinical trials and cohort studies on OPMD.
Keywords: oral potentially malignant disorder, malignant transformation, oral cancer, molecular mechanism, immune microenvironment, artificial intelligence
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
