About this Research Topic
Despite significant progress in understanding stroke pathology, translating cerebroprotection strategies into clinical practice remains a challenge. Recent studies highlight that the complexity of stroke-induced damage may underpin the difficulties in bridging experimental findings with therapeutic outcomes. This Research Topic aims to explore the important factors of the blood-brain barrier (BBB) in stroke, emphasizing novel insights and potential therapeutic targets that could advance stroke treatment. We invite contributions that cover a range of topics, including but not limited to:
1. Circadian influences on BBB dynamics post-stroke: Investigations into how circadian rhythms affect BBB integrity and disruption following a stroke, including potential windows for therapeutic intervention.
2. BBB and immune system interplay: Insightful research on the interactions between the immune system and the BBB post-stroke.
3. Impact of comorbidities on BBB disruption in stroke: Analyses of how existing comorbid conditions influence BBB integrity and stroke outcomes.
4. The impact of age and sex on BBB disruption following stroke: Studies examining how age and sex influence BBB disruption and stroke pathophysiology, offering a lens into tailored therapeutic approaches.
5. Strategies to enhance cross-BBB drug delivery: Innovations in overcoming BBB transport challenges for improved cerebral protection, including novel drug delivery systems and therapeutic molecules.
We believe that this Research Topic will shed light on the critical yet often overlooked aspects of BBB research in the context of stroke. By compiling the latest research and perspectives on BBB integrity, disruption, and repair mechanisms post-stroke, we aim to pave the way for future stroke treatment targeting the blood-brain barrier.
1. Circadian influences on BBB dynamics post-stroke: Investigations into how circadian rhythms affect BBB integrity and disruption following a stroke, including potential windows for therapeutic intervention.
2. BBB and immune system interplay: Insightful research on the interactions between the immune system and the BBB post-stroke.
3. Impact of comorbidities on BBB disruption in stroke: Analyses of how existing comorbid conditions influence BBB integrity and stroke outcomes.
4. The impact of age and sex on BBB disruption following stroke: Studies examining how age and sex influence BBB disruption and stroke pathophysiology, offering a lens into tailored therapeutic approaches.
5. Strategies to enhance cross-BBB drug delivery: Innovations in overcoming BBB transport challenges for improved cerebral protection, including novel drug delivery systems and therapeutic molecules.
We believe that this Research Topic will shed light on the critical yet often overlooked aspects of BBB research in the context of stroke. By compiling the latest research and perspectives on BBB integrity, disruption, and repair mechanisms post-stroke, we aim to pave the way for future stroke treatment targeting the blood-brain barrier.
Keywords: Blood-Brain Barrier, BBB, Stroke, Blood-Brain Barrier Disruption, Post-Stroke
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
