The gut microbiota plays a pivotal role in maintaining immune homeostasis and influencing systemic health. Dysbiosis of the gut microbiota has been implicated in various immune-related inflammatory diseases, including inflammatory bowel disease, diabetes, rheumatoid arthritis, and systemic lupus erythematosus. The intricate interactions between the gut microbiota and the immune system are largely mediated through microbial metabolites, which are derived from dietary components and host substrates and subsequently modified by gut bacteria. These metabolites exert significant effects not only within the intestinal tract but also on distal organs, mediated through diverse immune cells such as T cells, B cells, dendritic cells, and macrophages. This Research Topic aims to compile the latest research exploring the role of gut microbiota in modulating immune function and contributing to inflammatory diseases, thereby providing foundational knowledge and innovative approaches for prevention, diagnosis, and treatment.
This research topic is dedicated to elucidating key gut microbiota and their metabolites that regulate immune responses, summarizing their effects on various immune cells, and examining the relationships between gut microbiota and immune-mediated inflammatory diseases. By collecting state-of-the-art research and comprehensive reviews, this issue aims to serve as a vital resource for researchers, clinicians, and healthcare professionals. It seeks to offer insights into the potential of harnessing the gut microbiome for managing and mitigating the impacts of immune-related inflammatory diseases, ultimately advancing human health.
This study welcomes original research and high-quality review articles related to the theme. Potential themes include, but are not limited to:
(1) The relationship between the gut microbiota and the immune system;
(2) The crosstalk between gut microbiota and immune-related inflammatory diseases;
(3) The impact of Microbiota-based therapies on the immune system in inflammatory diseases,including probiotics, prebiotics, bacteriophage, bacterial metabolites, and integrative traditional and Western medicines.
(4) Exploring the key gut microbiota and their metabolites as biomarkers for diagnosis of immune-related inflammatory diseases.
Keywords:
Gut Microbiota, Metabolites, Innate Immunity, Adaptive Immunity, Inflammatory Diseases
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
The gut microbiota plays a pivotal role in maintaining immune homeostasis and influencing systemic health. Dysbiosis of the gut microbiota has been implicated in various immune-related inflammatory diseases, including inflammatory bowel disease, diabetes, rheumatoid arthritis, and systemic lupus erythematosus. The intricate interactions between the gut microbiota and the immune system are largely mediated through microbial metabolites, which are derived from dietary components and host substrates and subsequently modified by gut bacteria. These metabolites exert significant effects not only within the intestinal tract but also on distal organs, mediated through diverse immune cells such as T cells, B cells, dendritic cells, and macrophages. This Research Topic aims to compile the latest research exploring the role of gut microbiota in modulating immune function and contributing to inflammatory diseases, thereby providing foundational knowledge and innovative approaches for prevention, diagnosis, and treatment.
This research topic is dedicated to elucidating key gut microbiota and their metabolites that regulate immune responses, summarizing their effects on various immune cells, and examining the relationships between gut microbiota and immune-mediated inflammatory diseases. By collecting state-of-the-art research and comprehensive reviews, this issue aims to serve as a vital resource for researchers, clinicians, and healthcare professionals. It seeks to offer insights into the potential of harnessing the gut microbiome for managing and mitigating the impacts of immune-related inflammatory diseases, ultimately advancing human health.
This study welcomes original research and high-quality review articles related to the theme. Potential themes include, but are not limited to:
(1) The relationship between the gut microbiota and the immune system;
(2) The crosstalk between gut microbiota and immune-related inflammatory diseases;
(3) The impact of Microbiota-based therapies on the immune system in inflammatory diseases,including probiotics, prebiotics, bacteriophage, bacterial metabolites, and integrative traditional and Western medicines.
(4) Exploring the key gut microbiota and their metabolites as biomarkers for diagnosis of immune-related inflammatory diseases.
Keywords:
Gut Microbiota, Metabolites, Innate Immunity, Adaptive Immunity, Inflammatory Diseases
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.