About this Research Topic
The field of tissue homeostasis is pivotal in understanding how biological systems maintain stability amidst internal and external changes. Homeostasis is a dynamic process that ensures equilibrium within cells, organs, and entire organisms. Despite its importance, the molecular mechanisms that underpin homeostasis remain partially understood, particularly concerning the role of cellular signaling pathways. Key pathways such as Wnt, Hedgehog, Dpp/BMP, and Notch are well-documented for their roles in animal development, yet their specific contributions to homeostasis are not fully elucidated. Current research suggests that these pathways may act as sensors, guides, and controllers of cellular behavior in response to stress or stimuli. However, the complexity increases as multiple pathways often activate simultaneously, necessitating a coordinated effort to maintain tissue homeostasis. This highlights a significant gap in our understanding, emphasizing the need for further investigation into how these pathways interact and integrate to sustain homeostasis.
This research topic aims to elucidate the cooperative and integrative roles of key signaling pathways in maintaining tissue homeostasis. The primary objective is to uncover the molecular mechanisms and functions of these pathways during homeostasis across various biological levels. By addressing these questions, the research seeks to advance our understanding of how signaling pathways contribute to the maintenance of stable biological conditions, particularly in the context of stress, aging, and disease.
To gather further insights into the complex interactions of signaling pathways in tissue homeostasis, we welcome articles addressing, but not limited to, the following themes:
- Exploring and identifying critical components and regulators within signal transduction pathways, focusing on their roles in biological homeostasis.
- Investigating the specific functions and impacts of cellular signaling during tissue and organ development, and their implications for maintaining stability under varying conditions.
- Deciphering the critical functions of signaling for tissue and organ maintenance and survival upon exposure to stimuli or stress, and their significance for homeostasis.
- Examining the roles of signaling pathways, such as Wnt, Hedgehog, Dpp/BMP, and Notch, in aging and disease progression, with an emphasis on their contributions to homeostasis.
- Investigating how multiple signaling pathways collaborate and integrate in response to stresses or stimuli to maintain tissue homeostasis.
This research topic aims to elucidate the cooperative and integrative roles of key signaling pathways in maintaining tissue homeostasis. The primary objective is to uncover the molecular mechanisms and functions of these pathways during homeostasis across various biological levels. By addressing these questions, the research seeks to advance our understanding of how signaling pathways contribute to the maintenance of stable biological conditions, particularly in the context of stress, aging, and disease.
To gather further insights into the complex interactions of signaling pathways in tissue homeostasis, we welcome articles addressing, but not limited to, the following themes:
- Exploring and identifying critical components and regulators within signal transduction pathways, focusing on their roles in biological homeostasis.
- Investigating the specific functions and impacts of cellular signaling during tissue and organ development, and their implications for maintaining stability under varying conditions.
- Deciphering the critical functions of signaling for tissue and organ maintenance and survival upon exposure to stimuli or stress, and their significance for homeostasis.
- Examining the roles of signaling pathways, such as Wnt, Hedgehog, Dpp/BMP, and Notch, in aging and disease progression, with an emphasis on their contributions to homeostasis.
- Investigating how multiple signaling pathways collaborate and integrate in response to stresses or stimuli to maintain tissue homeostasis.
Keywords: signaling pathway, homeostasis, organ development, organ maintenance, stress
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
