Multifunctional nanomaterials: Stand in the Center of Cancer Therapy as well as Tissue Regeneration and Repair

The field of multifunctional nanomaterials stands at the forefront of Cancer Therapy and Tissue Regeneration. Diseases such as cancer and tissue/organ failure are leading causes of mortality worldwide, with their incidence rising due to the growing and aging global population. This has created an urgent need for advanced therapies that can improve therapeutic responses and promote tissue regeneration, ultimately prolonging patient survival. Nanobiomaterials, with their unique physicochemical properties, have been extensively explored for disease treatment, particularly in tumor therapy and tissue regeneration. Despite significant progress, challenges remain in integrating highly efficacious, specific, and personalized multimodal therapies. Recent advancements in nanomedicine have introduced new platforms and techniques for efficient and safe combination therapies. Nano-based drug delivery systems have revolutionized the approach to preferentially delivering theranostic agents to disease sites, enhancing therapeutic targeting, reducing systemic toxicity, and overcoming multi-drug resistance. Additionally, multifunctional biomaterials have demonstrated the ability to modulate the tumor and tissue micro-environment, such as hypoxia, acidity, and redox conditions, due to their inherent properties. These advancements highlight the potential of multifunctional biomaterials in achieving optimal and synergistic combination therapies.

This Research Topic aims to explore the elaborate design and development of nanomaterials for cancer combination therapies, investigate unique approaches for cancer treatments based on multifunctional biomaterials, and address the current challenges in cancer treatment. The goal is to provide new insights and promising strategies for cancer combination therapies and tissue regeneration, advancing the development and clinical application of nanomaterials. Specific questions to be answered include how to enhance the efficacy and specificity of nanomaterial-based therapies, how to overcome existing barriers in cancer treatment, and how to effectively integrate these therapies into clinical practice.

To gather further insights into the boundaries of multifunctional nanomaterials in Cancer Therapy and Tissue Regeneration, we welcome articles addressing, but not limited to, the following themes:
• Design and synthesis of multifunctional nanomaterials for cancer therapy
• Nano-based drug delivery systems for targeted cancer treatment
• Modulation of tumor and tissue micro-environments using nanomaterials
• Overcoming multi-drug resistance with nanomaterial-based therapies
• Clinical translation and application of nanomaterials in cancer and tissue regeneration
• Safety and toxicity assessment of multifunctional nanomaterials
• Innovative approaches for integrating multimodal therapies using nanomaterials