About this Research Topic
High dietary sodium consumption is rising worldwide and is associated with increased hypertension and cardiovascular disease. However, people with salt-sensitivity of blood pressure (SSBP), defined as acute changes in blood pressure that mirror dietary sodium intake, are more vulnerable to salt-induced cardiovascular morbidity and mortality than salt-resistant individuals. SSBP is an independent risk factor that disproportionally affects African Americans and women. The American Heart Association (AHA) recommends a Na+ intake of 2300 milligrams (mg) or 5845 mg NaCl) daily, but less than 10% of Americans observe this recommendation. In fact, the average American eats more than 3,400 mg of Na+ a day. Despite the alarmingly high consumption of Na+ and the adverse impact on CVD and stroke risk, the mechanism of SSBP is poorly understood, and it remains an untreatable cardiovascular risk with no widely available diagnostic tool or therapy.
The problem we would like to tackle in this Research Topic is to improve the poorly understood mechanism of salt-sensitivity of blood pressure (SSBP) and its significant impact on cardiovascular morbidity and mortality. This Research Topic aims to compile original research articles, reviews, and commentaries that enhance our understanding of the mechanisms underlying salt sensitivity in blood pressure and potential therapeutic targets. It particularly focuses on the physiological and pathophysiological aspects of dietary sodium’s effects on the immune, cardiovascular, renal and central nervous systems, exploring a novel area of research to find therapeutic targets to treat SSBP.
The current Research Topic aims to cover promising, recent, and novel research trends in salt sensitivity of blood pressure and associated disciplines. We welcome studies on the mechanism of salt sensitivity of blood pressure, novel technologies, and interventions, addressing the dangers and benefits of dietary salt in health and disease. We invite submissions covering a broad range of topics, including but not limited to:
• Interaction between dietary salt and immune cells that may impact hypertension and its effects on cardiovascular, kidney, and other chronic diseases.
• The role of kidney, gut, brain, and vascular systems in causing salt-sensitivity of blood pressure.
• The impact of high or low salt intake on the progression of cardiovascular and kidney diseases.
• Molecular mechanisms and metabolic pathways underlying the effects of dietary salt on hypertension and the subsequent development of end-organ damage.
• Developmental origins and environmental determinants of SSBP and hypertension.
• New therapeutic strategies to treat salt-induced hypertension and innovative technologies and interventions exploring the link between dietary salt and hypertension-associated cardiovascular, kidney, and other chronic diseases.
• Research seeking biomarkers and therapeutic targets to provide potential prognosis and treatment for salt-sensitivity of blood pressure.
• Economic and health implications of salt reduction initiatives or salt substitutes.
By encompassing these areas, we aim to advance our understanding of the complex role dietary salt plays in health and disease and foster effective strategies to mitigate its adverse effects.
The problem we would like to tackle in this Research Topic is to improve the poorly understood mechanism of salt-sensitivity of blood pressure (SSBP) and its significant impact on cardiovascular morbidity and mortality. This Research Topic aims to compile original research articles, reviews, and commentaries that enhance our understanding of the mechanisms underlying salt sensitivity in blood pressure and potential therapeutic targets. It particularly focuses on the physiological and pathophysiological aspects of dietary sodium’s effects on the immune, cardiovascular, renal and central nervous systems, exploring a novel area of research to find therapeutic targets to treat SSBP.
The current Research Topic aims to cover promising, recent, and novel research trends in salt sensitivity of blood pressure and associated disciplines. We welcome studies on the mechanism of salt sensitivity of blood pressure, novel technologies, and interventions, addressing the dangers and benefits of dietary salt in health and disease. We invite submissions covering a broad range of topics, including but not limited to:
• Interaction between dietary salt and immune cells that may impact hypertension and its effects on cardiovascular, kidney, and other chronic diseases.
• The role of kidney, gut, brain, and vascular systems in causing salt-sensitivity of blood pressure.
• The impact of high or low salt intake on the progression of cardiovascular and kidney diseases.
• Molecular mechanisms and metabolic pathways underlying the effects of dietary salt on hypertension and the subsequent development of end-organ damage.
• Developmental origins and environmental determinants of SSBP and hypertension.
• New therapeutic strategies to treat salt-induced hypertension and innovative technologies and interventions exploring the link between dietary salt and hypertension-associated cardiovascular, kidney, and other chronic diseases.
• Research seeking biomarkers and therapeutic targets to provide potential prognosis and treatment for salt-sensitivity of blood pressure.
• Economic and health implications of salt reduction initiatives or salt substitutes.
By encompassing these areas, we aim to advance our understanding of the complex role dietary salt plays in health and disease and foster effective strategies to mitigate its adverse effects.
Keywords: Blood Pressure, Cardiovascular Disease, Dietary Salt, Immune Cells, Kidney
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
