Latin America is renowned for its rich diversity, encompassing distinctive genetic backgrounds, environmental exposures, and lifestyle factors. With an aging population, cancer has emerged as one of the foremost causes of death in this region. Latin American individuals have been shown to differ in cancer susceptibility, treatment response, and progression compared to other ethnicities, potentially due to the region's distinctive genetic ancestry, which reflects a captivating admixture between Native Americans, Europeans, and Sub-Saharan Africans. This complex molecular landscape creates opportunities for new and exciting ground-breaking investigations.
Cancer poses a significant health burden in Latin America, with increasing incidence rates and limited resources for prevention, diagnosis, and treatment. The challenges in controlling this pathology are worsened by uneven and often limited access to advanced molecular tests, which are critical for accurate diagnosis and personalized treatment. These disparities lead to unequal health outcomes, affecting not only patients’ prognoses but also limiting our understanding of the disease among a diverse population. To address these issues, we aim to collect studies on the molecular characterization of cancer in Latin America, focusing on data from cutting-edge technologies like next-Generation sequencing, single-Cell RNA sequencing, and liquid biopsy, among others. This will enable a deeper investigation into tumor heterogeneity, revealing unique biomarkers and molecular patterns that can enhance our understanding of the disease's pathophysiology and guide the development of customized treatment strategies for Latin American individuals.
We welcome Original Research, Review, Mini Review and Perspective articles on molecular cancer research in Latin America. The themes include, but are not limited to:
• Epidemiological studies investigating cancer incidence, prevalence, and risk factors.
• Molecular studies with emphasis on genetic ancestry.
• Molecular mechanisms underlying cancer development and progression.
• Biomarker discovery and validation for cancer diagnosis, prognosis, and treatment response.
• Translational research bridging basic science discoveries to clinical applications.
• Therapeutic strategies targeting molecular pathways.
• Challenges and opportunities in cancer precision medicine and personalized therapy approaches.
• Artificial intelligence and machine learning techniques in cancer research.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases that are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords:
Neoplasms, Latin America, Molecular Diagnostic Techniques, Ancestry, Health Disparities
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Latin America is renowned for its rich diversity, encompassing distinctive genetic backgrounds, environmental exposures, and lifestyle factors. With an aging population, cancer has emerged as one of the foremost causes of death in this region. Latin American individuals have been shown to differ in cancer susceptibility, treatment response, and progression compared to other ethnicities, potentially due to the region's distinctive genetic ancestry, which reflects a captivating admixture between Native Americans, Europeans, and Sub-Saharan Africans. This complex molecular landscape creates opportunities for new and exciting ground-breaking investigations.
Cancer poses a significant health burden in Latin America, with increasing incidence rates and limited resources for prevention, diagnosis, and treatment. The challenges in controlling this pathology are worsened by uneven and often limited access to advanced molecular tests, which are critical for accurate diagnosis and personalized treatment. These disparities lead to unequal health outcomes, affecting not only patients’ prognoses but also limiting our understanding of the disease among a diverse population. To address these issues, we aim to collect studies on the molecular characterization of cancer in Latin America, focusing on data from cutting-edge technologies like next-Generation sequencing, single-Cell RNA sequencing, and liquid biopsy, among others. This will enable a deeper investigation into tumor heterogeneity, revealing unique biomarkers and molecular patterns that can enhance our understanding of the disease's pathophysiology and guide the development of customized treatment strategies for Latin American individuals.
We welcome Original Research, Review, Mini Review and Perspective articles on molecular cancer research in Latin America. The themes include, but are not limited to:
• Epidemiological studies investigating cancer incidence, prevalence, and risk factors.
• Molecular studies with emphasis on genetic ancestry.
• Molecular mechanisms underlying cancer development and progression.
• Biomarker discovery and validation for cancer diagnosis, prognosis, and treatment response.
• Translational research bridging basic science discoveries to clinical applications.
• Therapeutic strategies targeting molecular pathways.
• Challenges and opportunities in cancer precision medicine and personalized therapy approaches.
• Artificial intelligence and machine learning techniques in cancer research.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases that are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords:
Neoplasms, Latin America, Molecular Diagnostic Techniques, Ancestry, Health Disparities
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.