Optic neuropathy represents a significant area of concern within both glaucoma and neuro-ophthalmology, impacting a broad spectrum of patients worldwide. The optic nerve, a crucial component of the visual pathway, can suffer damage from various etiologies, leading to visual impairment or blindness. Glaucoma, a leading cause of irreversible blindness, primarily involves progressive optic neuropathy characterized by retinal ganglion cell loss and optic nerve head changes. Concurrently, neuro-ophthalmic disorders, including ischemic, inflammatory, and hereditary optic neuropathies, offer a complex array of diagnostic and therapeutic.

This research topic aims to address the multifaceted nature of optic neuropathy at the confluence of glaucoma and neuro-ophthalmology. The primary objective is to bridge gaps between these subspecialties by encouraging a holistic approach to optic nerve research. By inviting articles that span from basic anatomical studies and pathophysiological insights to cutting-edge diagnostic techniques and therapeutic interventions, we hope to elucidate the underlying mechanisms of optic nerve diseases. Additionally, this research topic seeks to highlight recent advancements in imaging technologies, genetic research, and novel treatment modalities that promise to transform clinical practice. Ultimately, this collection aims to foster interdisciplinary collaboration, stimulate innovative research, and translate findings into tangible clinical benefits for patients suffering from optic neuropathy.

We invite contributions that provide a comprehensive exploration of optic neuropathy, particularly at the intersection of glaucoma and neuro-ophthalmology. Specific themes include:

• Detailed studies on the anatomy and physiology of the optic nerve.

• Pathophysiological mechanisms underlying glaucomatous and non-glaucomatous optic neuropathies.

• Advances in diagnostic imaging and biomarker identification. Innovations in medical and surgical treatments for optic nerve diseases.

• The role of genetics and molecular biology in understanding optic neuropathies.

Case reports and series that offer novel insights into rare optic neuropathies.

Authors are encouraged to submit original research articles, review articles, clinical trials, case reports, and perspective pieces. This research topic aims to gather a diverse array of manuscripts to enhance our collective understanding and spur future research directions in the field of optic neuropathy.

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Frontiers in Ophthalmology

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