About this Research Topic
The prevalence of obesity has skyrocketed globally over the past four decades, with a projected majority of adults worldwide being either overweight or obese by 2030. Obesity disrupts the balance of endocrine hormones like leptin and adiponectin, thereby impacting energy metabolism and fat accumulation.
Obesity is closely associated with the onset and exacerbation of various diseases, especially respiratory conditions such as asthma and COPD. These respiratory disorders pose even greater challenges when complicated with obesity. Moreover, obesity is linked to higher mortality rates in lung cancer and interferes with the effectiveness of PD-L1 antibody drug therapy. Endocrine hormone imbalances resulting from obesity disrupt adaptive immune systems, including Th1, Th2, and Th17 cells, as well as innate lymphocytes, thus significantly affecting respiratory diseases. Despite this understanding, the intricate molecular mechanisms remain unclear. Additionally, aspects such as the extent of metabolic dysfunction and the impact on comorbid conditions like depression and cardiovascular disease, which may influence the progression of respiratory illnesses, require further investigation.
Conversely, evidence suggests that weight loss can enhance the management of bronchial asthma exacerbated by obesity. The Research Topic aims to offer empirical support for the beneficial effects of weight loss on chronic respiratory disorders, encompassing asthma, COPD, lung cancer, and respiratory infections, and to elucidate the molecular mechanisms.
The scope of the Research Topic encompasses a wide range of areas related to the impact of obesity-induced hormonal imbalances on respiratory diseases, particularly COPD, asthma, lung cancer, and pneumonia. Contributors are encouraged to address specific topics such as:
● Impact of respiratory diseases on hormonal imbalance: Exploring how hypoxic conditions or airway inflammation affect hormone synthesis, secretion, and signaling pathways
● Exploring the physiological or hormonal changes induced by obesity and their impact on the efficacy of drug treatments for COPD, asthma, cancer and infectious diseases
● Investigating the impact of hormone imbalance normalization or weight loss on respiratory diseases.
Obesity is closely associated with the onset and exacerbation of various diseases, especially respiratory conditions such as asthma and COPD. These respiratory disorders pose even greater challenges when complicated with obesity. Moreover, obesity is linked to higher mortality rates in lung cancer and interferes with the effectiveness of PD-L1 antibody drug therapy. Endocrine hormone imbalances resulting from obesity disrupt adaptive immune systems, including Th1, Th2, and Th17 cells, as well as innate lymphocytes, thus significantly affecting respiratory diseases. Despite this understanding, the intricate molecular mechanisms remain unclear. Additionally, aspects such as the extent of metabolic dysfunction and the impact on comorbid conditions like depression and cardiovascular disease, which may influence the progression of respiratory illnesses, require further investigation.
Conversely, evidence suggests that weight loss can enhance the management of bronchial asthma exacerbated by obesity. The Research Topic aims to offer empirical support for the beneficial effects of weight loss on chronic respiratory disorders, encompassing asthma, COPD, lung cancer, and respiratory infections, and to elucidate the molecular mechanisms.
The scope of the Research Topic encompasses a wide range of areas related to the impact of obesity-induced hormonal imbalances on respiratory diseases, particularly COPD, asthma, lung cancer, and pneumonia. Contributors are encouraged to address specific topics such as:
● Impact of respiratory diseases on hormonal imbalance: Exploring how hypoxic conditions or airway inflammation affect hormone synthesis, secretion, and signaling pathways
● Exploring the physiological or hormonal changes induced by obesity and their impact on the efficacy of drug treatments for COPD, asthma, cancer and infectious diseases
● Investigating the impact of hormone imbalance normalization or weight loss on respiratory diseases.
Keywords: Obesity, COPD, Asthma, Lung cancer, Pneumonia
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
