G protein-coupled receptors (GPCRs) represent a vast and diverse family of membrane proteins that play crucial roles in cellular communication and signal transduction, and have gained significant relevance in recent decades due to their role as therapeutic targets for numerous marketed drugs. Notably, some GPCRs, referred to as orphan GPCRs, form a unique subset for which natural ligands have not yet been identified, leaving their physiological and pathological roles largely unexplored. Consequently, there is limited information about these receptors, which could have significant implications in the development and progression of neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's diseases.
The goal of this Research Topic is to advance our understanding of orphan G protein-coupled receptors (GPCRs) and their involvement in neurodegenerative diseases. Recent studies have begun to elucidate the physiological and pathological roles of these orphan GPCRs using knockout or transgenic mice, as well as pharmacological investigations. These findings are crucial for understanding molecular mechanisms, which in turn influence behavioral outcomes in animal models. By elucidating the functional roles of orphan GPCRs in neurodegenerative processes, we seek to identify novel therapeutic targets that have the potential to revolutionize treatment paradigms.
The main objective of this research topic is to integrate emerging knowledge from researchers dedicated to the field of orphan receptors. This includes computational models, in vitro and in vivo studies, and clinical trials, aiming to enhance our understanding of GPCRs and propose novel solutions for neurodegenerative diseases. Ultimately, we invite comprehensive articles that thoroughly address the goals of this research topic, and look forward to our collaboration.
Keywords:
Orphan GPCR, G protein-coupled receptors, Fatty acids, Deorphanization GPCR, Neurodegenerative disease, Alzheimer's disease, Parkinson's disease, Huntington's disease, Brain, Neuromodulation
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
G protein-coupled receptors (GPCRs) represent a vast and diverse family of membrane proteins that play crucial roles in cellular communication and signal transduction, and have gained significant relevance in recent decades due to their role as therapeutic targets for numerous marketed drugs. Notably, some GPCRs, referred to as orphan GPCRs, form a unique subset for which natural ligands have not yet been identified, leaving their physiological and pathological roles largely unexplored. Consequently, there is limited information about these receptors, which could have significant implications in the development and progression of neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's diseases.
The goal of this Research Topic is to advance our understanding of orphan G protein-coupled receptors (GPCRs) and their involvement in neurodegenerative diseases. Recent studies have begun to elucidate the physiological and pathological roles of these orphan GPCRs using knockout or transgenic mice, as well as pharmacological investigations. These findings are crucial for understanding molecular mechanisms, which in turn influence behavioral outcomes in animal models. By elucidating the functional roles of orphan GPCRs in neurodegenerative processes, we seek to identify novel therapeutic targets that have the potential to revolutionize treatment paradigms.
The main objective of this research topic is to integrate emerging knowledge from researchers dedicated to the field of orphan receptors. This includes computational models, in vitro and in vivo studies, and clinical trials, aiming to enhance our understanding of GPCRs and propose novel solutions for neurodegenerative diseases. Ultimately, we invite comprehensive articles that thoroughly address the goals of this research topic, and look forward to our collaboration.
Keywords:
Orphan GPCR, G protein-coupled receptors, Fatty acids, Deorphanization GPCR, Neurodegenerative disease, Alzheimer's disease, Parkinson's disease, Huntington's disease, Brain, Neuromodulation
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.