Inflammatory Pathways in Cardiometabolic Diseases: Mechanisms, Biomarkers, and Therapeutic Insights

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About this Research Topic

Submission deadlines

  1. Manuscript Submission Deadline 10 February 2025

  2. This Research Topic is still accepting articles.

Background

The inflammatory microenvironment is a pivotal factor in the development and progression of cardiometabolic diseases (CMD), encompassing a complex network of cells and molecules that arise from inflammatory responses. This environment, comprising immune cells, extracellular matrix, growth factors, and other inflammatory mediators, significantly influences cardiovascular tissue repair, disease progression, and treatment efficacy. Recent studies have highlighted the role of the inflammatory microenvironment in accelerating CMD through mechanisms such as proinflammatory cytokines, immune cell infiltration, endothelial dysfunction, oxidative stress, and metabolic disorders. Despite these insights, there remains a critical need to delve deeper into the specific mechanisms, biomarkers, and therapeutic applications associated with the inflammatory microenvironment in CMD. Current research is beginning to unravel these complexities, yet gaps persist in understanding the precise roles of different immune cells, inflammation-related molecules, and signaling pathways. Addressing these gaps could unveil new targets and strategies for clinical interventions, offering hope for improved management of CMD.

This research topic aims to collect and publish a series of cutting-edge studies on the role of the inflammatory microenvironment in metabolic cardiovascular diseases. The primary objective is to highlight the main findings and latest progress in this field, thereby expanding research directions and enriching the existing body of knowledge. By exploring potential therapeutic applications, the research seeks to provide novel insights into the management of metabolic cardiovascular diseases. Specific questions include understanding the biological mechanisms mediated by the inflammatory microenvironment, the application of inflammation-related biomarkers, and the clinical efficacy of anti-inflammatory therapies.

To gather further insights into the inflammatory microenvironment's role in metabolic cardiovascular diseases, we welcome articles addressing, but not limited to, the following themes:
- Biological mechanisms of CMD development mediated by the inflammatory microenvironment, including exploration of inflammatory mechanisms in diseases such as atherosclerosis, atrial fibrillation, and heart failure.
- Application of inflammation-related biomarkers in cardiovascular disease diagnosis, focusing on the relationship between adipose tissue and CMD under inflammatory conditions.
- Interaction between the inflammatory microenvironment and metabolic disorders, examining how conditions like insulin resistance and hyperlipidemia exacerbate CMD through inflammatory pathways.
- Clinical application of anti-inflammatory therapy in CMD, including targeted effects of anti-inflammatory drugs and evaluation of their efficacy and safety in CMD treatment.

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Keywords: inflammation, metabolic cardiovascular disease, mechanisms, biomarkers, therapeutic implications

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