In the intricate landscape of neuroscience, understanding the synaptic dynamics in stress-dependent disorders presents a compelling avenue for research. Synapses, the fundamental units of neuronal communication, undergo a delicate balance of formation, maturation, stabilization, and pruning in the healthy brain. However, when exposed to chronic stress, these dynamic processes become dysregulated, instigating structural impairments and cognitive deficits. Dysregulated synaptic formation may result in aberrant circuitry, while impaired stabilization mechanisms compromise synaptic strength and plasticity. Concurrently, excessive synaptic pruning may occur, dismantling crucial connections, and compromising information transmission and processing. This dysregulation not only undermines the structural integrity of the brain but also precipitates cognitive impairments and emotional dysregulation characteristic of stress-related disorders. These phenomena underscore the critical need to delve deeper into the mechanisms underlying synaptic alterations in stress-related pathologies and facilitate the development of therapeutic strategies.
In elucidating the synaptic dynamics in stress-dependent disorders, we confront the complexity of neurobiological adaptations to environmental challenges. Synaptic formation, stabilization, and pruning, inherent to normal brain development and function, become dysregulated under conditions of stress, precipitating structural impairments and cognitive deficits. Unraveling the intricacies of synaptic alterations in stress-related pathologies holds promise for the development of targeted interventions to mitigate the deleterious effects of stress on brain and behavior.
This Research Topic focuses on the molecular and structural mechanisms that govern synaptic dynamics in stress-dependent pathologies. The aim of this Research Topic is to gather recent advances in the field of synapse formation and its dysregulation in stress-dependent disorders. We welcome both original and review articles that provide insight into this field.
We welcome authors to submit articles focusing on, but not limited to the following topics:
- Molecular and structural mechanisms of synapse elimination in chronic stress-dependent disorders
- Regulatory mechanisms of synapse formation which are perturbed in a chronic stress-dependent context.
- Behavioral outcomes that are due to a disruption in synapse dynamics in stress-dependent pathologies.
- Therapeutic targets, which are promising candidates in tackling the disrupting effects if chronic stress on spine dynamics.
Keywords:
Synaptic Plasticity, spine dynamics, stress-dependent pathologies, Synaptic formation, emotional dysregulation, stress disorders, tress-dependent disorders
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
In the intricate landscape of neuroscience, understanding the synaptic dynamics in stress-dependent disorders presents a compelling avenue for research. Synapses, the fundamental units of neuronal communication, undergo a delicate balance of formation, maturation, stabilization, and pruning in the healthy brain. However, when exposed to chronic stress, these dynamic processes become dysregulated, instigating structural impairments and cognitive deficits. Dysregulated synaptic formation may result in aberrant circuitry, while impaired stabilization mechanisms compromise synaptic strength and plasticity. Concurrently, excessive synaptic pruning may occur, dismantling crucial connections, and compromising information transmission and processing. This dysregulation not only undermines the structural integrity of the brain but also precipitates cognitive impairments and emotional dysregulation characteristic of stress-related disorders. These phenomena underscore the critical need to delve deeper into the mechanisms underlying synaptic alterations in stress-related pathologies and facilitate the development of therapeutic strategies.
In elucidating the synaptic dynamics in stress-dependent disorders, we confront the complexity of neurobiological adaptations to environmental challenges. Synaptic formation, stabilization, and pruning, inherent to normal brain development and function, become dysregulated under conditions of stress, precipitating structural impairments and cognitive deficits. Unraveling the intricacies of synaptic alterations in stress-related pathologies holds promise for the development of targeted interventions to mitigate the deleterious effects of stress on brain and behavior.
This Research Topic focuses on the molecular and structural mechanisms that govern synaptic dynamics in stress-dependent pathologies. The aim of this Research Topic is to gather recent advances in the field of synapse formation and its dysregulation in stress-dependent disorders. We welcome both original and review articles that provide insight into this field.
We welcome authors to submit articles focusing on, but not limited to the following topics:
- Molecular and structural mechanisms of synapse elimination in chronic stress-dependent disorders
- Regulatory mechanisms of synapse formation which are perturbed in a chronic stress-dependent context.
- Behavioral outcomes that are due to a disruption in synapse dynamics in stress-dependent pathologies.
- Therapeutic targets, which are promising candidates in tackling the disrupting effects if chronic stress on spine dynamics.
Keywords:
Synaptic Plasticity, spine dynamics, stress-dependent pathologies, Synaptic formation, emotional dysregulation, stress disorders, tress-dependent disorders
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.