About this Research Topic
Neuroscience has increasingly focused on the synaptic mechanisms underlying stress-dependent disorders, revealing critical insights that could inform therapeutic advancements. Synapses, pivotal in neuronal communication, maintain a balance of growth and decline in a healthy brain. Under chronic stress, this balance is disrupted, causing structural damages and cognitive disturbances. These impairments not only compromise the brain's structural integrity but are also implicated in the cognitive and emotional irregularities observed in stress-related disorders. This context underscores the importance of this research area.
This Research Topic aims to elucidate the synaptic dynamics in stress-induced neurological disorders, addressing how chronic stress modulates synaptic formation, maturation, stability, and pruning. Understanding the changes in synaptic behavior that lead to structural and functional brain anomalies will reveal more about the pathogenesis of these conditions. This work will also explore potential therapeutic interventions focusing on synaptic resilience and recovery.
To gather further insights into the scope of this study, we welcome articles that elaborate, but are not limited to, the following themes:
• Mechanisms of synaptic dysregulation under stress
• Relationships between synaptic impairment and cognitive deficits
• Neuroimaging of synaptic changes in stress conditions
• Development of interventions targeting synaptic stability and plasticity
• Comparative studies on synaptic behavior in healthy vs. stress-affected brains
This Research Topic aims to elucidate the synaptic dynamics in stress-induced neurological disorders, addressing how chronic stress modulates synaptic formation, maturation, stability, and pruning. Understanding the changes in synaptic behavior that lead to structural and functional brain anomalies will reveal more about the pathogenesis of these conditions. This work will also explore potential therapeutic interventions focusing on synaptic resilience and recovery.
To gather further insights into the scope of this study, we welcome articles that elaborate, but are not limited to, the following themes:
• Mechanisms of synaptic dysregulation under stress
• Relationships between synaptic impairment and cognitive deficits
• Neuroimaging of synaptic changes in stress conditions
• Development of interventions targeting synaptic stability and plasticity
• Comparative studies on synaptic behavior in healthy vs. stress-affected brains
Keywords: Synaptic Plasticity, spine dynamics, stress-dependent pathologies, Synaptic formation, emotional dysregulation, stress disorders, tress-dependent disorders
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
