About this Research Topic
Tumors are complexes composed of malignant cells and the tumor microenvironment, including various immune cell types, cancer-related fibroblasts, endothelial cells, and other tissue-resident cell types. The tumor microenvironment plays a crucial role in the initiation, progression, invasion, infiltration, metastasis, diffusion, and growth of tumors. Understanding the complex interactions between tumor cells and tumor microenvironments is crucial for the rational development of effective anti-cancer treatments. Cell therapies, including immune cell therapy (CAR-T, NK, CAR-NK, etc.) and stem cell therapies, are new key treatment methods for diseases that cannot be cured with traditional drugs. Cell therapies have shown significant effectiveness and targeted specificity in the treatment of leukemias and some solid tumors. How to obtain cell therapy products with stable quality and significant therapeutic effects and use them for the treatment of liver tumors that are currently lacking effective treatments in clinical practice is the ultimate direction of efforts in the field of cell therapy.
This Research Topic covers the bullet points below
1) Investigate specific factors or molecular mechanisms underlying parenchymal cell activation during severe or chronic inflammation (e.g. cell signaling pathway) and their possible influence on tumor progression.
2) Explore the effects of immune cells or immune signaling pathways on the behavior of tumor cells and tumor-initiating cells.
3) Explain the interaction between liver cancer cells and the niche and how this relationship works in tumor cell proliferation and fate determination using single-cell RNA sequencing, single nuclear RNA sequencing, or spatial transcriptomics.
4) Application of immunotherapy and cell/stem cell therapies in the treatment of liver cancer.
5) Study on the mechanism of cellular therapy for liver diseases.
6) Exploring the role and mechanism of cellular products derived from tissues during the perinatal period in the treatment of diseases.
7) Research the relationship between cellular aging and the occurrence and development of liver cancer and induction therapy of liver cancer aging.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
This Research Topic covers the bullet points below
1) Investigate specific factors or molecular mechanisms underlying parenchymal cell activation during severe or chronic inflammation (e.g. cell signaling pathway) and their possible influence on tumor progression.
2) Explore the effects of immune cells or immune signaling pathways on the behavior of tumor cells and tumor-initiating cells.
3) Explain the interaction between liver cancer cells and the niche and how this relationship works in tumor cell proliferation and fate determination using single-cell RNA sequencing, single nuclear RNA sequencing, or spatial transcriptomics.
4) Application of immunotherapy and cell/stem cell therapies in the treatment of liver cancer.
5) Study on the mechanism of cellular therapy for liver diseases.
6) Exploring the role and mechanism of cellular products derived from tissues during the perinatal period in the treatment of diseases.
7) Research the relationship between cellular aging and the occurrence and development of liver cancer and induction therapy of liver cancer aging.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: immune cell, cell therapy, Liver Cancer
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
