About this Research Topic
Inflammation is implicated in the pathogenesis of various diseases, including cardiovascular, pulmonary and renal diseases. The induction of inflammation involves different cell types and cytokines, which is further amplified by the crosstalk among these cells and cytokines. In response to organ injury, damage-associated molecular patterns and pathogen-associated molecular patterns bind to the specific pattern recognition receptors, and subsequently transduce the extracellular stimuli to intracellular signaling network to induce the expression and release of inflammatory cytokines. These cytokines recruit resident or circulating leukocytes to the injury site, which in turn produce excessive inflammatory mediators, creating a vicious circle. While inflammation initially helps to remove the injured tissue or cell debris necessary for tissue healing, uncontrolled inflammation eventually leads to cell senescence, pyroptosis, apoptosis and organ dysfunction. Therefore, elucidating the molecular mechanisms of inflammation and optimizing the inflammatory process are promising therapeutic strategies for treating organ injury.
The goal of this Research Topic is to provide a forum to advance research on elucidating the molecular mechanisms of inflammation in organ injury and to develop efficient therapeutic strategies for these diseases.
We welcome the submission of Reviews, Original Research articles, Perspectives, and Methods covering, but are not restricted to the following topics:
1. Inflammatory modulation based on gene delivery or natural products for organ injury.
2. Investigation of molecular mechanisms for inflammation during organ injury using multi-omics approaches, such as single-cell sequencing, transcriptomics, proteomics and metabolomics.
3. The role of inflammation in mediating cross-talk between cells or organs.
4. Diagnostic value of plasma inflammatory cytokines for organ injury.
Please note: Manuscripts consisting solely of computational analysis of bioinformatics or public genomic or transcriptional databases without validation (independent cohort or in vitro or in vivo biological validation) are outside the scope of this section and are not accepted as part of this research topic. Manuscript dealing with traditional or complementary medicine without a very strong focus on immunological parameters are out of scope for this journal.
The goal of this Research Topic is to provide a forum to advance research on elucidating the molecular mechanisms of inflammation in organ injury and to develop efficient therapeutic strategies for these diseases.
We welcome the submission of Reviews, Original Research articles, Perspectives, and Methods covering, but are not restricted to the following topics:
1. Inflammatory modulation based on gene delivery or natural products for organ injury.
2. Investigation of molecular mechanisms for inflammation during organ injury using multi-omics approaches, such as single-cell sequencing, transcriptomics, proteomics and metabolomics.
3. The role of inflammation in mediating cross-talk between cells or organs.
4. Diagnostic value of plasma inflammatory cytokines for organ injury.
Please note: Manuscripts consisting solely of computational analysis of bioinformatics or public genomic or transcriptional databases without validation (independent cohort or in vitro or in vivo biological validation) are outside the scope of this section and are not accepted as part of this research topic. Manuscript dealing with traditional or complementary medicine without a very strong focus on immunological parameters are out of scope for this journal.
Keywords: Inflammation, Pathogenesis, Cytokines, Organ Dysfunction
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
