About this Research Topic
This research topic focuses on the intricate interplay between the host immune response and potential therapeutic targets. Viral infections can exacerbate allergic conditions by dysregulating the immune system, leading to heightened inflammatory responses. Key to this process is the interaction between viral antigens and host immune cells, which can promote the release of pro-inflammatory cytokines and chemokines, aggravating allergic symptoms. Therapeutic targets include cytokine signaling pathways, regulatory T cells, and checkpoint inhibitors, which can modulate the immune response to restore balance and reduce inflammation. For instance, targeting interleukin-4 (IL-4) and interleukin-13 (IL-13) pathways has shown promise in diminishing allergic inflammation by preventing the Th2-type immune response typical in allergies. Furthermore, enhancing the function of regulatory T cells (Tregs) can suppress overactive immune responses, offering a potential pathway for therapeutic intervention. Overall, understanding the molecular mechanisms underpinning the immune response to viral infections can inform the development of targeted therapies that mitigate allergic reactions, improving patient outcomes. Additionally, Adoptive cell transfer, particularly the use of virus-specific T cells or chimeric antigen receptor (CAR) T cells, offers a targeted approach by enhancing the immune system's ability to recognize and eliminate infected cells. Moreover, strategies like therapeutic vaccines and monoclonal antibodies are being developed to provide immediate immunity and neutralize viruses directly. Together, these immunomodulatory interventions hold significant potential not only for treating acute viral infections but also for managing chronic viral diseases by rebalancing immune responses and promoting long-term viral control.
Keywords: host immune response, therapeutic targets, viral, infection
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