About this Research Topic
The expression of theta activity in cerebral structures as the hippocampus and prefrontal cortex is related to information processing. The role of serotonin in modulating theta activity is evident but we are still lacking critical information about the molecular mechanisms whereby serotonin modulates the electrical activity of the brain. It was initially proposed that serotonin plays a role in sustaining no-cholinergic theta activity. However, after different evidence demonstrated an impairing effect of serotonin on the synchronization of hippocampal theta activity, it is now accepted that serotonin could underlie a specific type of theta activity. Yet, the evidence supporting this assumption is far from conclusive.
A more complex role of serotonin in the modulation of both theta activity and cognition is emerging in light of the fact that serotonergic modulator action occurs through different subcortical nuclei and cortical structures influencing cognitive abilities. In addition, the role of serotonin can vary within each structure, leading to different effects of serotonin manipulation on different systems, cell types (like, for example, pyramidal neurons and small regulatory interneurons) and cognitive processes.
A more comprehensive review of the evidence for the role of serotonin in regulating the electrical neuronal (theta) activity and in modulating cognitive processes is needed to revisit the different findings proposed so far. Ideally, we should integrate approaches from both electrical synchronization at theta frequencies and behavioral studies within different cognitive domains.
The goal of this Research Topic is to evaluate the role of serotonin in the modulation of theta activity and cognition, through a comprehensive review of the existing evidence, and a critical reassessment of the main hypotheses on this topic. We welcome both experimental work and reviews focused on the relationship between serotonin and cognition, serotonin and theta activity or serotonin, theta activity and cognition. Manuscripts can focus on (but are not limited to) to nodal cerebral structure (such as septum, posterior hypothalamus, hippocampus, prefrontal cortex) or circuits, along with various cognitive abilities modulated by serotonin.
Neuropharmacology welcomes submissions of the following article types: Brief Research Report, Case Report, Clinical Trial, Community Case Study, Correction, Data Report, Editorial, General Commentary, Hypothesis & Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Study Protocol, Systematic Review, Technology and Code.
Topic Editor Prof. Fabio Macciardi is a Professor (emeritus) in the Department of Molecular Psychiatry at the University of California, Irvine (UCI) and serves as Chief Scientific Officer (CSO) at Cognigenics.
A more complex role of serotonin in the modulation of both theta activity and cognition is emerging in light of the fact that serotonergic modulator action occurs through different subcortical nuclei and cortical structures influencing cognitive abilities. In addition, the role of serotonin can vary within each structure, leading to different effects of serotonin manipulation on different systems, cell types (like, for example, pyramidal neurons and small regulatory interneurons) and cognitive processes.
A more comprehensive review of the evidence for the role of serotonin in regulating the electrical neuronal (theta) activity and in modulating cognitive processes is needed to revisit the different findings proposed so far. Ideally, we should integrate approaches from both electrical synchronization at theta frequencies and behavioral studies within different cognitive domains.
The goal of this Research Topic is to evaluate the role of serotonin in the modulation of theta activity and cognition, through a comprehensive review of the existing evidence, and a critical reassessment of the main hypotheses on this topic. We welcome both experimental work and reviews focused on the relationship between serotonin and cognition, serotonin and theta activity or serotonin, theta activity and cognition. Manuscripts can focus on (but are not limited to) to nodal cerebral structure (such as septum, posterior hypothalamus, hippocampus, prefrontal cortex) or circuits, along with various cognitive abilities modulated by serotonin.
Neuropharmacology welcomes submissions of the following article types: Brief Research Report, Case Report, Clinical Trial, Community Case Study, Correction, Data Report, Editorial, General Commentary, Hypothesis & Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Study Protocol, Systematic Review, Technology and Code.
Topic Editor Prof. Fabio Macciardi is a Professor (emeritus) in the Department of Molecular Psychiatry at the University of California, Irvine (UCI) and serves as Chief Scientific Officer (CSO) at Cognigenics.
Keywords: Serotonin, Theta activity, Learning, Memory, Reversal, Preservation, Anxiety
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