About this Research Topic
Extracellular vesicles (EVs) are nanoparticles with diameters ranging from 50 to 200 nm, released from various types of cells. EVs contain a heterogeneous mix of particles: microvesicles, exosomes, apoptotic bodies, and exomeres. These particles are categorized by their biogenesis pathways, particle size, surface molecules, and cargo content, which include nucleic acids, proteins, lipids, and biomolecules. Surface molecules carried over from their origin cells are crucial for recognition and uptake by recipient cells. Circulating EVs play a significant role in cell-to-cell communication by transporting cargo to distant recipient cells. Identifying surface molecules, quantitatively analyzing circulating EV numbers, and analyzing EV contents are innovative approaches to understanding the pathophysiological dynamics in human diseases.
In this Research Topic, we focus on EVs in hematological disorders. Circulating red blood cells (RBCs) carry oxygen to all body cells, supporting cellular activity. Anemia is a major pathological problem in hematological disorders, inducing hypoxic stress in various organs, including the brain, cardiovascular system, endothelial cells, muscles, liver, and kidneys. Thus, erythroid EVs are an important area of focus in this Research Topic. Another significant source of circulating EVs comes from platelets, which play roles in hemostasis and vascular endothelial injury. Recent studies have reported that platelet-derived EVs promote endothelial damage in cardiovascular/metabolic disorders and hematological disorders. Immuno-competent cells also release EVs during infection or immune-related pathological steps.
The aim of this Research Topic is to achieve a comprehensive understanding of EV biology in the context of hematological disorders and to enhance our understanding of their roles in pathophysiology. We welcome all types of studies, including technological advancements, omics research on EV contents, clinical applications, and therapeutic approaches. We invite authors to contribute to this field of knowledge by submitting any type of manuscript, including original research articles, reviews, and opinion articles. For more information regarding article types, please visit the dedicated Article types page via the following link: www.frontiersin.org/journals/medicine/for-authors/article-types
In this Research Topic, we focus on EVs in hematological disorders. Circulating red blood cells (RBCs) carry oxygen to all body cells, supporting cellular activity. Anemia is a major pathological problem in hematological disorders, inducing hypoxic stress in various organs, including the brain, cardiovascular system, endothelial cells, muscles, liver, and kidneys. Thus, erythroid EVs are an important area of focus in this Research Topic. Another significant source of circulating EVs comes from platelets, which play roles in hemostasis and vascular endothelial injury. Recent studies have reported that platelet-derived EVs promote endothelial damage in cardiovascular/metabolic disorders and hematological disorders. Immuno-competent cells also release EVs during infection or immune-related pathological steps.
The aim of this Research Topic is to achieve a comprehensive understanding of EV biology in the context of hematological disorders and to enhance our understanding of their roles in pathophysiology. We welcome all types of studies, including technological advancements, omics research on EV contents, clinical applications, and therapeutic approaches. We invite authors to contribute to this field of knowledge by submitting any type of manuscript, including original research articles, reviews, and opinion articles. For more information regarding article types, please visit the dedicated Article types page via the following link: www.frontiersin.org/journals/medicine/for-authors/article-types
Keywords: Extracellular Vesicles, Hematological Disorders, Anemia, Platelet-Derived EVs, Pathophysiology
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
