About this Research Topic
Development and regeneration are fundamental processes that utilize common mechanisms to coordinate biological processes such as tissue formation and damage repair by generating functional tissues. Stem cells play a pivotal role in both processes by providing a reservoir of multipotent or pluripotent progenitor cells. While developmental disorders significantly impact human health, degenerative disorders and injury responses are also of critical interest from a health perspective. The study on the stem cell niche in both processes could potentially lead to groundbreaking discoveries, aiding in the development of novel therapies and treatments.
Stem cells facilitate tissue and organ development, yet stem cell-mediated adult tissue regeneration is restricted in most mammals. Regenerative capabilities vary widely across species, with some losing the stem cell/progenitor pool by adulthood. Understanding this process will help reactivate the tissue regeneration process in adults. Studies have made progress in elucidating the mechanism of action of stem cells during development and regeneration. Over the past few decades, investigations in highly regenerative organisms have identified factors critical for regeneration, and many are redundant from early development.
Areas covered under this Research Topic include but are not limited to:
• Stem cell functions and mechanisms in tissue and organ development in multicellular organisms.
• Cellular and molecular mechanisms of stem cell populations in prenatal tissue repair and injury.
• Alterations in stem cell function in developmental disorders.
• Stem cell defects affecting various tissue regeneration outcomes in adult animals.
• Advanced techniques in stem cell manipulation and transplantations aimed at correcting developmental defects and improving adult tissue regeneration.
We invite submissions that will make a unique contribution to the field, including primary research articles, review articles, and novel protocols and techniques. Your work has the potential to significantly advance the understanding of the role of stem cells in regeneration and development, and we value your contribution to the scientific community.
Stem cells facilitate tissue and organ development, yet stem cell-mediated adult tissue regeneration is restricted in most mammals. Regenerative capabilities vary widely across species, with some losing the stem cell/progenitor pool by adulthood. Understanding this process will help reactivate the tissue regeneration process in adults. Studies have made progress in elucidating the mechanism of action of stem cells during development and regeneration. Over the past few decades, investigations in highly regenerative organisms have identified factors critical for regeneration, and many are redundant from early development.
Areas covered under this Research Topic include but are not limited to:
• Stem cell functions and mechanisms in tissue and organ development in multicellular organisms.
• Cellular and molecular mechanisms of stem cell populations in prenatal tissue repair and injury.
• Alterations in stem cell function in developmental disorders.
• Stem cell defects affecting various tissue regeneration outcomes in adult animals.
• Advanced techniques in stem cell manipulation and transplantations aimed at correcting developmental defects and improving adult tissue regeneration.
We invite submissions that will make a unique contribution to the field, including primary research articles, review articles, and novel protocols and techniques. Your work has the potential to significantly advance the understanding of the role of stem cells in regeneration and development, and we value your contribution to the scientific community.
Keywords: Stem cells, Development, Regeneration, Re-programing, Stem cell therapy, Progenitors
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
