About this Research Topic
The number of multi antibiotic-resistant pathogens is worryingly increasing and are mostly associated with isolates from nosocomial infections. In recent years, the Infectious Disease Society of America begun to refer a group of nosocomial bacteria as “ESKAPE” which includes Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species. These pathogens are frequently implied in life-threatening and persistent infections, especially in immunocompromised individuals. Importantly, during acute infection ESKAPE bacteria can survive and overwhelm host defenses, thus leading to persistent infections which worsen the progression of the infectious disease. Eventually, the eradication of established ESKAPE infections is harsh since they employ multiple mechanisms to develop antibiotic resistance, such as i) structural modification either of the antibiotic or its binding site; ii) reduced intracellular accumulation, iii) biofilm formation.
Alternative approaches to combat pathogens persistent infections are the host-directed therapy (HDT), anti-virulence therapy and ultimately the bacteriophage therapy.
The relevance of ESKAPE infections pose a global warning for human health and the reduced approaches to counter their infections call for the development of new therapeutic strategies. Therefore, the present Research Topic aims to increase the knowledge on how ESKAPE pathogens survive and overcome both endogenous and exogenous (antimicrobial compounds) host defenses. Additionally, we sought to provide new insights into possible alternative approaches which could subvert ESKAPE infection.
We strongly encourage but not limit submissions addressing the following sub-topics:
- ESKAPE survival to host defenses
- Host mechanisms to eradicate ESKAPE bacteria.
- New insights into HDT, anti-virulence and bacteriophage therapies against ESKAPE
- ESKAPE modulation of host defenses
- ESKAPE antibiotic resistance
Alternative approaches to combat pathogens persistent infections are the host-directed therapy (HDT), anti-virulence therapy and ultimately the bacteriophage therapy.
The relevance of ESKAPE infections pose a global warning for human health and the reduced approaches to counter their infections call for the development of new therapeutic strategies. Therefore, the present Research Topic aims to increase the knowledge on how ESKAPE pathogens survive and overcome both endogenous and exogenous (antimicrobial compounds) host defenses. Additionally, we sought to provide new insights into possible alternative approaches which could subvert ESKAPE infection.
We strongly encourage but not limit submissions addressing the following sub-topics:
- ESKAPE survival to host defenses
- Host mechanisms to eradicate ESKAPE bacteria.
- New insights into HDT, anti-virulence and bacteriophage therapies against ESKAPE
- ESKAPE modulation of host defenses
- ESKAPE antibiotic resistance
Keywords: ESKAPE infections, Antimicrobial resistance, Immune response against ESKAPE, HDT, Phagetherapy, Anti-virulence therapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
