About this Research Topic
The adaptive immune response spans 450 million years of evolution, encompassing species from fish to humans. Today, substantial progress in sequencing and assembly methodologies and technologies enables the recovery of complete immunoglobulin (IG) and T cell receptor (TR) loci. The scientific community needs IG and TR reference directories for each species. The biocuration effort to analyze the multigenic, highly conserved IG and TR gene families is of paramount importance. Several studies within and across species are underway to distinguish polymorphisms from mutations, identify haplotypes, and, through evolutionary studies, highlight the specificities of each genome.
The goal of this Research Topic is to address issues related to the immunoglobulin and T cell receptor genes and alleles area, including their challenges, potential solutions, and current success stories.
IG) and T cell receptor (TR) loci. We welcome studies, software tools, methodologies, and technologies that enhance the accurate and efficient identification of IG and TR. Analyses focusing on the exploration of the immune repertoire of a specific species are also welcome. Additionally, comparative genomics studies of the IG and TR loci are encouraged. Descriptions of databases carrying information on IG and TR, along with relevant points about these databases, are also welcome. Finally, the application of artificial intelligence methodologies to the aforementioned thematic areas is encouraged. We accept original articles, reviews, and short communications.
The goal of this Research Topic is to address issues related to the immunoglobulin and T cell receptor genes and alleles area, including their challenges, potential solutions, and current success stories.
IG) and T cell receptor (TR) loci. We welcome studies, software tools, methodologies, and technologies that enhance the accurate and efficient identification of IG and TR. Analyses focusing on the exploration of the immune repertoire of a specific species are also welcome. Additionally, comparative genomics studies of the IG and TR loci are encouraged. Descriptions of databases carrying information on IG and TR, along with relevant points about these databases, are also welcome. Finally, the application of artificial intelligence methodologies to the aforementioned thematic areas is encouraged. We accept original articles, reviews, and short communications.
Keywords: immunogenetics, immunoinforamtics, loci, immune repertoires, jawed vertebrates
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