Addressing Oxidative Stress in HIV: Pathogenesis, Diagnostics, and Therapeutic Innovations

Human Immunodeficiency Virus (HIV) infection remains a significant global health challenge, affecting millions of individuals worldwide. While antiretroviral therapy (ART) has transformed HIV into a manageable chronic condition, patients still face numerous complications, including oxidative stress-induced damage. Oxidative stress plays a crucial role in HIV pathogenesis, contributing to disease progression, immune dysfunction, and the development of comorbidities. Recent studies have highlighted the molecular mechanisms by which oxidative stress exacerbates HIV-related health issues, yet there remains a substantial gap in fully understanding these processes and developing effective mitigation strategies. Addressing oxidative stress in HIV represents a critical area of research to enhance patient outcomes and quality of life.

This research topic aims to explore the intricate relationship between oxidative stress and HIV infection while highlighting innovative strategies for mitigating oxidative damage in affected individuals. By bringing together leading researchers, clinicians, and experts in the field, we seek to investigate the molecular mechanisms underlying oxidative stress in HIV infection, explore the impact of oxidative stress on HIV pathogenesis, disease progression, and comorbidity development, and review current diagnostic methods for assessing oxidative stress markers in HIV-infected individuals. Additionally, we aim to showcase novel therapeutic interventions and mitigation strategies targeting oxidative stress in HIV, discuss the role of lifestyle modifications, nutrition, and adjunctive therapies in reducing oxidative burden and improving patient outcomes, and examine the interaction between oxidative stress and ART, including potential oxidative side effects and ways to counteract them.

To gather further insights into the complex interplay between oxidative stress and HIV infection, we welcome articles addressing, but not limited to, the following themes:
- Molecular mechanisms underlying oxidative stress in HIV infection
- Impact of oxidative stress on HIV pathogenesis, disease progression, and comorbidity development
- Current diagnostic methods for assessing oxidative stress markers in HIV-infected individuals
- Novel therapeutic interventions and mitigation strategies targeting oxidative stress in HIV
- Role of lifestyle modifications, nutrition, and adjunctive therapies in reducing oxidative burden and improving patient outcomes
- Interaction between oxidative stress and ART, including potential oxidative side effects and ways to counteract them
- Biomarkers of oxidative stress for early detection and monitoring of HIV progression
- Genetic and epigenetic factors influencing oxidative stress responses in HIV-infected individuals
- Role of oxidative stress in HIV-associated neurocognitive disorders
- Potential of antioxidant therapies in improving the efficacy of ART and reducing drug resistance

We welcome original research articles, reviews, perspectives, and other contributions that adhere to the journal's formatting and submission guidelines. Authors are encouraged to provide novel insights, rigorous methodology, and potential clinical implications in their submissions. Contributions from multidisciplinary perspectives are particularly valued to foster comprehensive discussions and advancements in this critical area of research.

Keywords: oxidative stress, HIV Pathogenesis, Antioxidant Therapy, Disease Progression, Comorbidities

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.