Functional interactions between hippocampal sharp-wave ripple (SWR) activity and cerebellar Purkinje cell activity represent a critical area of study in the field of neuroscience. The hippocampus, known for its role in memory formation and spatial navigation, generates SWRs predominantly within the CA1 region. These high-frequency oscillations are believed to be pivotal in memory consolidation and information transfer, particularly during periods of rest and sleep. In contrast, the cerebellum, home to principal Purkinje neurons in the cerebellar cortex, is primarily associated with various forms of motor coordination. Additionally, the cerebellum has been increasingly recognized for its involvement in non-motor cognitive functions.
Despite extensive individual research on hippocampal SWRs and cerebellar Purkinje cells, their direct functional interaction remains relatively elusive. Unraveling the neural mechanisms linking these two brain regions is crucial for understanding the development of memory deficits and related cognitive disorders and exploring potential therapeutic interventions.
This Research Topic aims to distribute experimental, theoretical, and modeling studies that broaden our comprehension of how the hippocampus and cerebellum collaboratively contribute to temporal coordination, cognitive functions, and memory processing across various states, such as sleeping, resting, and related behavioral conditions. The scope of this topic encompasses research involving both human subjects and animals, as well as computational models. It employs a range of interdisciplinary approaches to delve into the complex computational interplay between brain regions and their cross-regional communication.
Keywords:
hippocampus, cerebellum, non-motor cognitive functions, motor coordination, functional interactions, cerebellar Purkinje cell
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Functional interactions between hippocampal sharp-wave ripple (SWR) activity and cerebellar Purkinje cell activity represent a critical area of study in the field of neuroscience. The hippocampus, known for its role in memory formation and spatial navigation, generates SWRs predominantly within the CA1 region. These high-frequency oscillations are believed to be pivotal in memory consolidation and information transfer, particularly during periods of rest and sleep. In contrast, the cerebellum, home to principal Purkinje neurons in the cerebellar cortex, is primarily associated with various forms of motor coordination. Additionally, the cerebellum has been increasingly recognized for its involvement in non-motor cognitive functions.
Despite extensive individual research on hippocampal SWRs and cerebellar Purkinje cells, their direct functional interaction remains relatively elusive. Unraveling the neural mechanisms linking these two brain regions is crucial for understanding the development of memory deficits and related cognitive disorders and exploring potential therapeutic interventions.
This Research Topic aims to distribute experimental, theoretical, and modeling studies that broaden our comprehension of how the hippocampus and cerebellum collaboratively contribute to temporal coordination, cognitive functions, and memory processing across various states, such as sleeping, resting, and related behavioral conditions. The scope of this topic encompasses research involving both human subjects and animals, as well as computational models. It employs a range of interdisciplinary approaches to delve into the complex computational interplay between brain regions and their cross-regional communication.
Keywords:
hippocampus, cerebellum, non-motor cognitive functions, motor coordination, functional interactions, cerebellar Purkinje cell
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.