About this Research Topic
Ototoxicity, characterized by hearing loss and other auditory disturbances, is a significant adverse effect associated with various medications, such as aminoglycosides, loop diuretics, and notably cisplatin, which is widely utilized in chemotherapy. This condition not only diminishes the quality of life for affected individuals but also poses a considerable public health challenge. The widespread impact of drug-induced ototoxicity underscores the urgent need for effective prevention and therapeutic strategies. Recent studies have highlighted the complex interplay of genetic, molecular, and environmental factors contributing to ototoxicity, yet the precise mechanisms remain inadequately understood. Current research efforts are focused on elucidating these mechanisms and identifying potential therapeutic targets. However, there is a notable gap in translating these findings into clinical practice, necessitating further investigation into innovative prevention and treatment approaches.
This research topic aims to enhance our understanding of the mechanisms underlying drug-induced ototoxicity and to identify potential therapeutic targets for intervention. This effort aspires to facilitate the development of effective clinical solutions that can prevent or mitigate the adverse auditory effects of ototoxic drugs. By addressing these objectives, the research seeks to contribute to improved therapeutic strategies and patient outcomes, ultimately reducing the burden of ototoxicity on individuals and healthcare systems.
To gather further insights into the prevention and therapeutic intervention in drug-induced ototoxicity, we welcome articles addressing, but not limited to, the following themes:
- Investigate the morphological changes and pathological basis of drug-induced ototoxicity.
- Explore the biological mechanisms and pathways, including inflammation, immune responses, and cytokine signaling, that contribute to ototoxicity.
- Evaluate the protective effects and underlying mechanisms of drugs designed to alleviate ototoxicity, identifying new therapeutic targets.
- Review existing literature on drugs with known ototoxicity-alleviating properties and their mechanisms of action.
This research topic aims to enhance our understanding of the mechanisms underlying drug-induced ototoxicity and to identify potential therapeutic targets for intervention. This effort aspires to facilitate the development of effective clinical solutions that can prevent or mitigate the adverse auditory effects of ototoxic drugs. By addressing these objectives, the research seeks to contribute to improved therapeutic strategies and patient outcomes, ultimately reducing the burden of ototoxicity on individuals and healthcare systems.
To gather further insights into the prevention and therapeutic intervention in drug-induced ototoxicity, we welcome articles addressing, but not limited to, the following themes:
- Investigate the morphological changes and pathological basis of drug-induced ototoxicity.
- Explore the biological mechanisms and pathways, including inflammation, immune responses, and cytokine signaling, that contribute to ototoxicity.
- Evaluate the protective effects and underlying mechanisms of drugs designed to alleviate ototoxicity, identifying new therapeutic targets.
- Review existing literature on drugs with known ototoxicity-alleviating properties and their mechanisms of action.
Keywords: ototoxicity, hearing loss, drug-induced toxicity, aminoglycosides, cisplatin, therapeutic targets, protective agents, auditory health
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
