The exposome is a record of all environmental, biological, and lifestyle-related factors that individuals encounter from preconception onwards. This comprehensive framework is pivotal for elucidating the interactions among these diverse exposures and biological systems, particularly in their role in modulating immune function and thus contributing to the etiology and progression of autoimmune diseases. Autoimmunity, defined as the immune system's aberrant response against self-antigens, arises from a complex interplay of genetic susceptibility and environmental triggers. Investigating the role of the exposome in this multifactorial process requires a shift from the traditional “one exposure, one disease” paradigm to a more integrative exposomics approach. Such an approach is crucial for advancing our understanding of the cumulative and synergistic effects of multiple exposures on autoimmune disease risk and progression. By adopting this comprehensive view, we can better decipher the environmental contributions to autoimmunity and develop more effective prevention and intervention strategies.
This Research Topic is dedicated to elucidating the critical role of the exposome in the pathogenesis and modulation of autoimmune diseases across the lifespan. Its goal is to foster advancements in understanding how various external (environmental), personal (lifestyle), and internal factors, including infections, meteorological factors, pollution, diet, physical activity, sleep, circadian rhythms, stress, smoking, hormones, and the microbiota, interact with the immune system. Additionally, this Research Topic advocates for the standardization of research methodologies within the exposomics field. We invite contributions that provide novel insights, detailed exposomics studies, and technological innovations. By facilitating the exchange of knowledge among diverse research groups, this special issue aims to deepen our understanding of the exposome’s impact on autoimmunity and promote the development of targeted prevention and intervention strategies.
The scope of this Research Topic is to enhance the understanding of the exposome’s impact on autoimmunity. We are particularly interested in contributions that present innovative research or comprehensive literature reviews on topics including, but not limited to:
- Exposomics and autoimmunity
- Epigenetic research linking the exposome to autoimmune responses
- The significance of exposome factors in early life and their long-term autoimmune outcomes
- Exposome and specific autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes, multiple sclerosis, psoriasis, autoimmune thyroiditis)
- Cohort studies on the effect of the exposome on the development and progression of autoimmune diseases
- Diet and specific nutritional factors in relation to autoimmunity
- Impact of physical activity and exercise on autoimmune diseases
- Sleep and circadian rhythms and their influence on autoimmune diseases
- The effects of stress on autoimmunity
- The role of smoking in the development and progression of autoimmune diseases
- Pollution and xenobiotics and their impact on autoimmunity
- The role of infections in autoimmune diseases
- The impact of meteorological factors on autoimmunity
- The role of hormones in autoimmunity
- The impact of the microbiota in autoimmune diseases
- Innovative methods for the characterization and quantification of the exposome in relation to autoimmunity
- Comprehensive reviews and original research articles on all aspects of exposome and autoimmunity
Keywords:
Exposome, Autoimmunity, Exposomics, Functional exposomics, Environmental immunology, Environmental exposure, Autoimmune diseases, Epigenetics, Diet, Nutrition, Microbiota, Hormones, Physical activity, Exercise, Stress, Sleep, Circadian rhythms, Smoking, P
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
The exposome is a record of all environmental, biological, and lifestyle-related factors that individuals encounter from preconception onwards. This comprehensive framework is pivotal for elucidating the interactions among these diverse exposures and biological systems, particularly in their role in modulating immune function and thus contributing to the etiology and progression of autoimmune diseases. Autoimmunity, defined as the immune system's aberrant response against self-antigens, arises from a complex interplay of genetic susceptibility and environmental triggers. Investigating the role of the exposome in this multifactorial process requires a shift from the traditional “one exposure, one disease” paradigm to a more integrative exposomics approach. Such an approach is crucial for advancing our understanding of the cumulative and synergistic effects of multiple exposures on autoimmune disease risk and progression. By adopting this comprehensive view, we can better decipher the environmental contributions to autoimmunity and develop more effective prevention and intervention strategies.
This Research Topic is dedicated to elucidating the critical role of the exposome in the pathogenesis and modulation of autoimmune diseases across the lifespan. Its goal is to foster advancements in understanding how various external (environmental), personal (lifestyle), and internal factors, including infections, meteorological factors, pollution, diet, physical activity, sleep, circadian rhythms, stress, smoking, hormones, and the microbiota, interact with the immune system. Additionally, this Research Topic advocates for the standardization of research methodologies within the exposomics field. We invite contributions that provide novel insights, detailed exposomics studies, and technological innovations. By facilitating the exchange of knowledge among diverse research groups, this special issue aims to deepen our understanding of the exposome’s impact on autoimmunity and promote the development of targeted prevention and intervention strategies.
The scope of this Research Topic is to enhance the understanding of the exposome’s impact on autoimmunity. We are particularly interested in contributions that present innovative research or comprehensive literature reviews on topics including, but not limited to:
- Exposomics and autoimmunity
- Epigenetic research linking the exposome to autoimmune responses
- The significance of exposome factors in early life and their long-term autoimmune outcomes
- Exposome and specific autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes, multiple sclerosis, psoriasis, autoimmune thyroiditis)
- Cohort studies on the effect of the exposome on the development and progression of autoimmune diseases
- Diet and specific nutritional factors in relation to autoimmunity
- Impact of physical activity and exercise on autoimmune diseases
- Sleep and circadian rhythms and their influence on autoimmune diseases
- The effects of stress on autoimmunity
- The role of smoking in the development and progression of autoimmune diseases
- Pollution and xenobiotics and their impact on autoimmunity
- The role of infections in autoimmune diseases
- The impact of meteorological factors on autoimmunity
- The role of hormones in autoimmunity
- The impact of the microbiota in autoimmune diseases
- Innovative methods for the characterization and quantification of the exposome in relation to autoimmunity
- Comprehensive reviews and original research articles on all aspects of exposome and autoimmunity
Keywords:
Exposome, Autoimmunity, Exposomics, Functional exposomics, Environmental immunology, Environmental exposure, Autoimmune diseases, Epigenetics, Diet, Nutrition, Microbiota, Hormones, Physical activity, Exercise, Stress, Sleep, Circadian rhythms, Smoking, P
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.