About this Research Topic
Extracellular vesicles (EVs) have marked a significant shift in cancer research, introducing novel approaches for early diagnosis, targeted therapeutic delivery, and the development of personalized treatment strategies. We are thrilled to present this Research Topic that delves into the groundbreaking research of EVs and their transformative potential in advancing cancer therapy.
The primary objectives of this article collection focus on EVs' multifaceted role in cancer dynamics and their subsequent influence on the future of precision medicine. Firstly, the Topic aims to explore the mechanisms via which EVs manipulate cancer dynamics, including how EVs impact cellular communication and metastasis and uniquely contribute to immune evasion. In addition, we would like to highlight the advancements in the technological methodologies used to isolate, characterize, and modify EVs by bioengineering, specifically tuned for precision drug delivery applications. We also seek to uncover novel applications of EVs in the next generation of biomarkers. All these applications are expected to revolutionize the early detection and consistent monitoring of cancer. Finally, this Research Topi will also critically evaluate the translational challenges and regulatory specifications required for the integration of EV-based solutions into routine clinical practice.
Our collection will include a broad spectrum of topics pertinent to the use of EVs in cancer therapeutics, including:
• Mechanisms of EV biogenesis in cancer cells and their cargo selection.
• The interplay between EVs and tumour microenvironment communication, including immune system interactions.
• Mechanisms by which EVs mediate drug resistance and innovative approaches to counteract these mechanisms.
• Cutting-edge techniques for isolating and characterizing cancer-specific EVs.
• Bioengineering EVs for precision drug targeting and enhanced therapeutic outcomes.
• The role of EVs as diagnostic biomarkers for early detection and ongoing disease monitoring.
• Insights from clinical trials and case studies on EV-targeted cancer therapies.
• Evaluations of the current challenges and promising future directions for clinical implementation of EV-based treatments.
This Research Topic aims to captivate a diverse audience that includes cancer researchers, oncologists, pharmaceutical innovators, and biomedical engineers. By showcasing the latest breakthroughs and prospective research paths, we aim to inspire, foster collaboration ventures, and propel the development of EV-based cancer treatments from laboratory research to clinical application.
The primary objectives of this article collection focus on EVs' multifaceted role in cancer dynamics and their subsequent influence on the future of precision medicine. Firstly, the Topic aims to explore the mechanisms via which EVs manipulate cancer dynamics, including how EVs impact cellular communication and metastasis and uniquely contribute to immune evasion. In addition, we would like to highlight the advancements in the technological methodologies used to isolate, characterize, and modify EVs by bioengineering, specifically tuned for precision drug delivery applications. We also seek to uncover novel applications of EVs in the next generation of biomarkers. All these applications are expected to revolutionize the early detection and consistent monitoring of cancer. Finally, this Research Topi will also critically evaluate the translational challenges and regulatory specifications required for the integration of EV-based solutions into routine clinical practice.
Our collection will include a broad spectrum of topics pertinent to the use of EVs in cancer therapeutics, including:
• Mechanisms of EV biogenesis in cancer cells and their cargo selection.
• The interplay between EVs and tumour microenvironment communication, including immune system interactions.
• Mechanisms by which EVs mediate drug resistance and innovative approaches to counteract these mechanisms.
• Cutting-edge techniques for isolating and characterizing cancer-specific EVs.
• Bioengineering EVs for precision drug targeting and enhanced therapeutic outcomes.
• The role of EVs as diagnostic biomarkers for early detection and ongoing disease monitoring.
• Insights from clinical trials and case studies on EV-targeted cancer therapies.
• Evaluations of the current challenges and promising future directions for clinical implementation of EV-based treatments.
This Research Topic aims to captivate a diverse audience that includes cancer researchers, oncologists, pharmaceutical innovators, and biomedical engineers. By showcasing the latest breakthroughs and prospective research paths, we aim to inspire, foster collaboration ventures, and propel the development of EV-based cancer treatments from laboratory research to clinical application.
Keywords: Extracellular Vesicles, Cancer Therapies, Targeted Drug Delivery, Biomarkers, Translational Research, Precision Medicine
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
