Exploring Photodermatoses in Immune-Mediated Conditions: Pathophysiology and Clinical Management

Photobiology and photodermatoses, particularly in the context of immune-mediated diseases, represent a burgeoning field of research with significant clinical implications. Photodermatoses encompass a range of conditions characterized by abnormal reactions to light, which can be classified into primary (idiopathic) and secondary (photoaggravated) categories. Despite advancements in dermatology, the pathophysiological mechanisms underlying these conditions remain poorly understood. Current research has highlighted the prevalence of photosensitivity in patients with immune-mediated diseases such as psoriasis and atopic dermatitis, yet the precise relationship between these diseases and light-induced reactions is still under investigation. Recent studies have begun to explore the potential of photobiological tests to diagnose and manage these conditions, but their application in clinical settings is not widespread. This gap underscores the need for more comprehensive research to elucidate the mechanisms at play and to develop effective diagnostic and therapeutic strategies.

This research topic aims to investigate the intricate relationship between immune-mediated diseases and photobiology, with a particular focus on photosensitivity and photoaggravation. The primary objectives include identifying the prevalence and characteristics of photosensitivity in patients with immune-mediated diseases, understanding the underlying pathophysiological mechanisms, and evaluating the efficacy of potential treatments, such as oral antioxidants. Specific questions to be addressed include: What are the common photobiological responses in patients with immune-mediated diseases? How do these responses correlate with disease severity and progression? Can interventions like oral antioxidants mitigate photosensitivity in these patients?

To gather further insights into the complex interplay between immune-mediated diseases and photobiology, we welcome articles addressing, but not limited to, the following themes:
• The prevalence and characteristics of photosensitivity in immune-mediated diseases
• Pathophysiological mechanisms linking immune-mediated diseases and photodermatoses
• Diagnostic approaches, including the use of photobiological tests
• Case reports highlighting unique instances of photosensitivity in immune-mediated diseases
• The role of oral antioxidants and other treatments in managing photosensitivity
• Comparative studies on primary versus secondary photodermatoses in immune-mediated conditions
• Longitudinal studies tracking the progression of photosensitivity in immune-mediated diseases

By exploring these themes, we aim to advance our understanding of photodermatoses in the context of immune-mediated diseases and to foster the development of more effective diagnostic and therapeutic strategies.

We welcome original articles, reviews related to the main topic (immune-mediated diseases and photosensitivity), or case reports. The acceptance of unique cases may be considered if they show great interest to the scientific community.

Keywords: Immune-Mediated Diseases, photobioology, photodermatoses, phototest, atopic dermatitis, psoriasis

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.