Natural Products against Tropical Diseases: Potential Trojan Horse in Modern Medicine

  • 431

    Total views and downloads

About this Research Topic

Submission deadlines

  1. Manuscript Submission Deadline 24 January 2025

  2. This Research Topic is still accepting articles.

Background

Tropical diseases are major health hazards in warm-weather regions, mostly impacting populations in underdeveloped nations. These illnesses, which are frequently brought on by bacteria, viruses, and parasites, can cause serious illness, disability, and even death if they are not treated. Leishmaniasis, schistosomiasis, dengue fever, malaria, and Chagas disease are a few of the tropical illnesses that are most common.
Historically, natural products have played an essential role in combating tropical diseases, particularly in the case of malaria. Quinine, which is derived from the bark of the cinchona tree, was the first widely used antimalarial drug, revolutionizing the treatment and control of malaria in the 17th century. In the 20th century, the discovery of artemisinin from the plant Artemisia annua marked another milestone in antimalarial therapy. Artemisinin and its derivatives remain the most effective treatment for Plasmodium falciparum malaria, especially in combination therapies. Beyond malaria, other natural products have shown significant promise against various tropical diseases. For instance, berberine, an alkaloid present in several medicinal plants, exhibits potent antiprotozoal activity, making it a potential candidate for treating leishmaniasis and Chagas disease. Additionally, marine-derived compounds such as bryostatin-1 from the bryozoan Bugula neritina have shown potent activity against schistosomiasis. These examples underscore the vast potential of natural products as a treasure trove for new therapeutic agents against tropical diseases, offering hope for more effective and sustainable disease management strategies.
Natural goods are abundant sources of substances having medicinal qualities that have historically been used in medicine. These products are obtained from plants, animals, and microbes. Because many traditional treatments used in tropical areas are based on natural items, it is possible to treat or prevent tropical diseases with them. Tropical illnesses like leishmaniasis and malaria have grown resistant to traditional therapies, making them more challenging to cure. A wide range of chemical structures found in natural goods may be able to circumvent resistance processes and offer substitute therapeutic approaches. A common feature of natural goods is their bioactive molecules, which have a variety of pharmacological actions. These substances can interfere with pathogen growth, obstruct transmission, or alter host immune responses, among other phases of the infectious cycle of tropical illnesses. In addition, natural products are a great resource for the discovery and development of new drugs. Novel chemicals with therapeutic potential against tropical diseases can be identified by researchers by screening plant extracts, marine creatures, and microbial metabolites. This method has resulted in the discovery of numerous significant medications.
We therefore welcome submissions relating to the following sub-themes:
Examine various natural sources, such as microbes, plants, and marine life, for possible therapeutic substances to treat tropical illnesses.
Access the therapeutic efficacy of natural components and determine how they work to combat infections that cause tropical diseases.
Explore the techniques and approaches including bioinformatics, machine learning, and AI, used to find and create new medications such as natural product-based vaccines from natural sources to cure tropical illnesses.
Investigate the creation of combination medicines for increased efficacy against tropical diseases, as well as possible synergistic interactions between conventional medications and natural chemicals.
Examine the problems associated with medication resistance in tropical diseases and consider the potential benefits of natural products in addressing resistance mechanisms.
Evaluate the safety and effectiveness of natural product-based treatments for tropical illnesses, as well as the potential for practical use, by reviewing clinical studies and translational research projects.
Analyze regulatory frameworks and policy implications pertaining to the creation, licensing, and marketing of natural product-based treatments for tropical illnesses.
Determine how natural product-based treatments for the prevention and treatment of tropical illnesses affect public health, as well as the measures used to guarantee impacted populations have fair access to these medications.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Case Report
  • Classification
  • Clinical Trial
  • Community Case Study
  • Curriculum, Instruction, and Pedagogy
  • Data Report
  • Editorial
  • General Commentary

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Keywords: Natural Products, Bioactive Compounds, Tropical Diseases, Natural Medicine, Metabolites, Plant Derived Compounds.

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Frequently asked questions

  • Frontiers' Research Topics are collaborative hubs built around an emerging theme.Defined, managed, and led by renowned researchers, they bring communities together around a shared area of interest to stimulate collaboration and innovation.

    Unlike section journals, which serve established specialty communities, Research Topics are pioneer hubs, responding to the evolving scientific landscape and catering to new communities.

  • The goal of Frontiers' publishing program is to empower research communities to actively steer the course of scientific publishing. Our program was implemented as a three-part unit with fixed field journals, flexible specialty sections, and dynamically emerging Research Topics, connecting communities of different sizes and maturity.

    Research Topics originate from the scientific community. Many of our Research Topics are suggested by existing editorial board members who have identified critical challenges or areas of interest in their field.

  • As an editor, Research Topics will help you build your journal, as well as your community, around emerging, cutting-edge research. As research trailblazers, Research Topics attract high-quality submissions from leading experts all over the world.

    A thriving Research Topic can potentially evolve into a new specialty section if there is sustained interest and a growing community around it.

  • Each Research Topic must be approved by the specialty chief editor, and it falls under the editorial oversight of our editorial boards, supported by our in-house research integrity team. The same standards and rigorous peer review processes apply to articles published as part of a Research Topic as for any other article we publish.

    In 2023, 80% of the Research Topics we published were edited or co-edited by our editorial board members, who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, each vetted and formally approved by the specialty chief editor.

  • Publishing your article within a Research Topic with other related articles increases its discoverability and visibility, which can lead to more views, downloads, and citations. Research Topics grow dynamically as more published articles are added, causing frequent revisiting, and further visibility.

    As Research Topics are multidisciplinary, they are cross-listed in several fields and section journals – increasing your reach even more and giving you the chance to expand your network and collaborate with researchers in different fields, all focusing on expanding knowledge around the same important topic.

    Our larger Research Topics are also converted into ebooks and receive social media promotion from our digital marketing team.

  • Frontiers offers multiple article types, but it will depend on the field and section journals in which the Research Topic will be featured. The available article types for a Research Topic will appear in the drop-down menu during the submission process.

    Check available article types here 

  • Yes, we would love to hear your ideas for a topic. Most of our Research Topics are community-led and suggested by researchers in the field. Our in-house editorial team will contact you to talk about your idea and whether you’d like to edit the topic. If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. 

    Suggest your topic here 

  • A team of guest editors (called topic editors) lead their Research Topic. This editorial team oversees the entire process, from the initial topic proposal to calls for participation, the peer review, and final publications.

    The team may also include topic coordinators, who help the topic editors send calls for participation, liaise with topic editors on abstracts, and support contributing authors. In some cases, they can also be assigned as reviewers.

  • As a topic editor (TE), you will take the lead on all editorial decisions for the Research Topic, starting with defining its scope. This allows you to curate research around a topic that interests you, bring together different perspectives from leading researchers across different fields and shape the future of your field. 

    You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

  • As a topic editor, you're supported at every stage by our in-house team. You will be assigned a single point of contact to help you on both editorial and technical matters. Your topic is managed through our user-friendly online platform, and the peer review process is supported by our industry-first AI review assistant (AIRA).

  • If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. This provides you with valuable editorial experience, improving your ability to critically evaluate research articles and enhancing your understanding of the quality standards and requirements for scientific publishing, as well as the opportunity to discover new research in your field, and expand your professional network.

  • Yes, certificates can be issued on request. We are happy to provide a certificate for your contribution to editing a successful Research Topic.

  • Research Topics thrive on collaboration and their multi-disciplinary approach around emerging, cutting-edge themes, attract leading researchers from all over the world.

  • As a topic editor, you can set the timeline for your Research Topic, and we will work with you at your pace. Typically, Research Topics are online and open for submissions within a few weeks and remain open for participation for 6 – 12 months. Individual articles within a Research Topic are published as soon as they are ready.

    Find out more about our Research Topics

  • Our fee support program ensures that all articles that pass peer review, including those published in Research Topics, can benefit from open access – regardless of the author's field or funding situation.

    Authors and institutions with insufficient funding can apply for a discount on their publishing fees. A fee support application form is available on our website.

  • In line with our mission to promote healthy lives on a healthy planet, we do not provide printed materials. All our articles and ebooks are available under a CC-BY license, so you can share and print copies.

Participating Journals

Manuscripts can be submitted to this Research Topic via the main journal or any other participating journal.

Impact

  • 431Topic views
View impact