African swine fever (ASF) is a highly contagious disease caused by the African swine fever virus (ASFV), significantly affecting the development of the pig industry and causing overwhelming economic losses. However, no commercial vaccines against ASFV have been available, and relevant vaccines are still in the research stage.
With the continuous research of ASF in recent years, based on multiple technical routes including inactivation, attenuation, subunit, viral vector, and DNA vaccines, the excited progress has been made in the development of ASF vaccines, some promising ASF vaccine candidates have been evaluated in preclinical trials, showing the good application prospects, which broaden our understanding of ASF vaccine development strategy and evaluation patterns. but there were still some problems hindering its further development. The safety concerns with attenuated vaccine and the low protection efficacy with inactivation, subunit and viral vector vaccine, as more than half of ASFV gene function undefined, which needs to be further clarified.
This Research Topic focuses on undefined gene function during ASFV infection, and screened for the immune protection or virulence related gene, as to develop and evaluation of ASF vaccine candidates, the challenges in developing safe and efficacious ASF vaccines, and the application prospects of ASF vaccines, result in providing some insights or technical support for the systemic establishment of ASFV control.
We welcome submissions focusing on, but not limited to, the following subtopics:
Undefined gene function especially immune protection-related genes during ASFV infection
Safe and high-efficiency vaccine candidates against ASF or potential new sight contribute to ASF vaccine development.
Potential drug targets or small molecular compounds or antibodies support for inhibition or treatment of ASFV.
Keywords:
African Swine Fever Virus, Gene function, Pathogenesis, vaccine candidate, Antiviral infection
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
African swine fever (ASF) is a highly contagious disease caused by the African swine fever virus (ASFV), significantly affecting the development of the pig industry and causing overwhelming economic losses. However, no commercial vaccines against ASFV have been available, and relevant vaccines are still in the research stage.
With the continuous research of ASF in recent years, based on multiple technical routes including inactivation, attenuation, subunit, viral vector, and DNA vaccines, the excited progress has been made in the development of ASF vaccines, some promising ASF vaccine candidates have been evaluated in preclinical trials, showing the good application prospects, which broaden our understanding of ASF vaccine development strategy and evaluation patterns. but there were still some problems hindering its further development. The safety concerns with attenuated vaccine and the low protection efficacy with inactivation, subunit and viral vector vaccine, as more than half of ASFV gene function undefined, which needs to be further clarified.
This Research Topic focuses on undefined gene function during ASFV infection, and screened for the immune protection or virulence related gene, as to develop and evaluation of ASF vaccine candidates, the challenges in developing safe and efficacious ASF vaccines, and the application prospects of ASF vaccines, result in providing some insights or technical support for the systemic establishment of ASFV control.
We welcome submissions focusing on, but not limited to, the following subtopics:
Undefined gene function especially immune protection-related genes during ASFV infection
Safe and high-efficiency vaccine candidates against ASF or potential new sight contribute to ASF vaccine development.
Potential drug targets or small molecular compounds or antibodies support for inhibition or treatment of ASFV.
Keywords:
African Swine Fever Virus, Gene function, Pathogenesis, vaccine candidate, Antiviral infection
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.