Hematologic malignancies present unique challenges due to the complexity of bone marrow microenvironment. Hematologic malignant tumor cells achieve rapid proliferation through specific metabolic adaptation and immune escape to meet their energy needs and evade immune surveillance. These metabolic changes may affect the tumor cells and immune cells in the bone marrow microenvironment, thereby changing the tumor microenvironment and affecting the growth, proliferation, drug resistance and metastasis of tumor cells.
Despite significant advances in this field, several key questions remain unanswered. Some of the unresolved issues include:
(1) Metabolic adaptation: What specific metabolic adaptations of hematological malignant tumor cells affect the immune microenvironment? How do changes in bone marrow microenvironment metabolism affect immune cells? How do these adaptations differ from other solid tumors?
(2) Immunosuppressive mechanism: How do hematological malignancies crosstalk with immune cells to establish an immunosuppressive microenvironment? What are the underlying mechanisms of immune escape?
(3) Metabolism and drug resistance: How do the metabolic characteristics and immune microenvironment changes of hematological malignancies lead to therapeutic drug resistance, especially whether targeting specific metabolic pathways can overcome drug resistance and its specific mechanisms?
This project aims to promote the study and understanding of the metabolism and immune microenvironment of hematological malignancies. We actively encourage researchers to submit original research articles, reviews, and general reviews to advance the field. By bringing together researchers from different disciplines, we aim to provide a comprehensive perspective on cutting-edge issues in hematological malignancy metabolism and immune microenvironment research. We seek to promote interdisciplinary collaboration and knowledge exchange. This research topic welcomes submissions covering a wide range of areas, including but not limited to:
• Unique metabolic changes and regulatory mechanisms of hematological malignant tumor cells and immune cells;
• Interaction between immune cells and hematological malignant tumor cells;
• Influence of hematological malignancy metabolism on immunotherapy;
• Regulation of metabolism and immune response of hematological malignancies by microenvironmental factors;
• The relationship between metabolism and immune escape in hematological malignancies;
• Application of novel therapeutic strategies and drugs in the metabolism and immune microenvironment of hematological malignancies.
Keywords:
hematological malignancy, metabolism microenvironment, immune microenvironment, tumor-microenvironment crosstalk
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Hematologic malignancies present unique challenges due to the complexity of bone marrow microenvironment. Hematologic malignant tumor cells achieve rapid proliferation through specific metabolic adaptation and immune escape to meet their energy needs and evade immune surveillance. These metabolic changes may affect the tumor cells and immune cells in the bone marrow microenvironment, thereby changing the tumor microenvironment and affecting the growth, proliferation, drug resistance and metastasis of tumor cells.
Despite significant advances in this field, several key questions remain unanswered. Some of the unresolved issues include:
(1) Metabolic adaptation: What specific metabolic adaptations of hematological malignant tumor cells affect the immune microenvironment? How do changes in bone marrow microenvironment metabolism affect immune cells? How do these adaptations differ from other solid tumors?
(2) Immunosuppressive mechanism: How do hematological malignancies crosstalk with immune cells to establish an immunosuppressive microenvironment? What are the underlying mechanisms of immune escape?
(3) Metabolism and drug resistance: How do the metabolic characteristics and immune microenvironment changes of hematological malignancies lead to therapeutic drug resistance, especially whether targeting specific metabolic pathways can overcome drug resistance and its specific mechanisms?
This project aims to promote the study and understanding of the metabolism and immune microenvironment of hematological malignancies. We actively encourage researchers to submit original research articles, reviews, and general reviews to advance the field. By bringing together researchers from different disciplines, we aim to provide a comprehensive perspective on cutting-edge issues in hematological malignancy metabolism and immune microenvironment research. We seek to promote interdisciplinary collaboration and knowledge exchange. This research topic welcomes submissions covering a wide range of areas, including but not limited to:
• Unique metabolic changes and regulatory mechanisms of hematological malignant tumor cells and immune cells;
• Interaction between immune cells and hematological malignant tumor cells;
• Influence of hematological malignancy metabolism on immunotherapy;
• Regulation of metabolism and immune response of hematological malignancies by microenvironmental factors;
• The relationship between metabolism and immune escape in hematological malignancies;
• Application of novel therapeutic strategies and drugs in the metabolism and immune microenvironment of hematological malignancies.
Keywords:
hematological malignancy, metabolism microenvironment, immune microenvironment, tumor-microenvironment crosstalk
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.