Stress, Immunity, and Inflammation in Metabolic Disorders

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About this Research Topic

Submission deadlines

  1. Manuscript Submission Deadline 19 March 2025

  2. This Research Topic is still accepting articles.

    1. Check author guidelines

Background

Livestock animals (swine, sheep, goats, and cattle) and humans are often exposed to various forms of stressors during their lifetime. The stress can be caused by physical, physiological, and psychological factors. Heat stress, social stress, weaning, parturition, and the transition from pregnancy to lactation are just some of the most studied stressful events in both animals and human beings. These stressors can directly affect the immunocompetence of the animals and humans, often resulting in immune dysfunction. Moreover, stress can trigger inflammatory responses. The precise mechanisms and pathways involved in the impact of stress on immunity remain poorly defined, but at least stress affects the homeorhetic and homeostatic mechanisms. Most importantly, metabolic and endocrinal alterations are observed. Stress can activate certain signaling pathways that control immunity and inflammatory responses.

There is a need to better understand immunity and inflammation during these stressful periods to improve growth, productivity, reproduction, health, and welfare of both livestock and humans. Nutritional intervention can improve immune function and alleviate inflammatory responses, providing means to prevent the development and progression of disease. Existing research techniques have been critical in helping unravel the role nutrition and metabolism play in animal physiology, including the discovery of new biomarkers and understanding the molecular mechanisms involved. More research that applies modern techniques, such as multi-omics, to further understand the role of nutritional and dietary strategies in regulating inflammation and sustaining optimal immune balance in the battle against inflammation-related metabolic disorders is highly desired. Most importantly, studies investigating the effects of composite dietary patterns rather than just single nutrients are most welcome.

The aim of this research topic is to publish original research and review articles on the area of stress, immunity, and inflammation in metabolic disorders. Potential topics could include:

1. Determining the useful candidate markers of systemic inflammation in both humans and animals.
2. Defining and validating criteria to classify inflammation that is associated with impaired health or performance.
3. Discussing possible nutritional and dietary strategies that can regulate stress, immunity, and inflammation.
4. Exploring the consequences of different stressors on immune function.
5. Identifying the key signals that initiate the inflammatory state.
6. Methods for detecting inflammation in animals and cows.
7. Investigating the host factors that are differentially expressed during stressful events that impact the onset and resolution of inflammation.
8. Evaluating whether nutritional strategies can mitigate stress.
9. Identifying the common pathways linking stress to immunity and inflammation in metabolic diseases.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Case Report
  • Clinical Trial
  • Conceptual Analysis
  • Data Report
  • Editorial
  • General Commentary
  • Hypothesis and Theory
  • Methods

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Case Report
  • Clinical Trial
  • Conceptual Analysis
  • Data Report
  • Editorial
  • General Commentary
  • Hypothesis and Theory
  • Methods
  • Mini Review
  • Opinion
  • Original Research
  • Perspective
  • Review
  • Systematic Review
  • Technology and Code

Keywords: Stressors, Immunity, Inflammation, Nutritional intervention, Metabolic disorders

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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