About this Research Topic
Tumor is currently one of the biggest impediments to global health. The past decades witness the new therapy and approaches for the treatment and cure. This special issue aims to investigate gene-related metabolic and immunological therapies for the threat.
Metabolic pathway alterations in cancer cells signify crucial physiological shifts. Metabolic dysregulation stands as a hallmark feature of tumor cells, with their highly active metabolic pathways not only providing the energy and building blocks necessary for tumor growth and dissemination but also directly influencing the interaction between tumor cells. Key genes undergo transformations throughout tumor development, contributing to the aggressiveness of cancer. This research topic focuses on these genes' relationship with cancer progression and their potential as diagnostic markers and treatment targets. Special attention is given to genes like GLUT1, G6PD, TKTL1, PGI/AMF, ACLY, ACC1, FAS, RRM1, RRM2, and TYMS. Their overexpression in tumors and active role in cancer progression offer potential cancer therapy opportunities. The collection also validates their use in cancer diagnoses using a gene microarray database.
While cancer is not only regarded as a disease of pathological cells but also as one of immune hypofunction. Therefore, the application of the gene immunotherapy plays an important role in tumor treatment as well. This therapy integrating transgene delivery or modulating fund expression to directly modulate immune responses in vivo to treat cancer. The heterogeneous and patient-specific nature of cancer further underscores the need for personalized cellular therapies.
Areas to be covered in this Research topic may include but are not limited to:
• Metabolic Changes in Cancer Cells: We welcome research on the pivotal physiological shifts caused by metabolic alterations in cancer cells, including how these changes affect tumor growth and interaction.
• Genetic Role in Tumor Development: We invite studies on transformations in key genes during tumor growth, focusing on their overexpression and active role in cancer progression.
• Genes as Diagnostic and Treatment Aids: Submissions should explore the potential of genes as diagnostic markers or treatment targets, including the development and efficacy of gene-based therapies.
• Gene Immunotherapy & Personalized Treatments: We seek contributions on personalized gene immunotherapies, focusing on in vivo strategies to modulate immune responses, bearing in mind patient-specific tumor characteristics.
Metabolic pathway alterations in cancer cells signify crucial physiological shifts. Metabolic dysregulation stands as a hallmark feature of tumor cells, with their highly active metabolic pathways not only providing the energy and building blocks necessary for tumor growth and dissemination but also directly influencing the interaction between tumor cells. Key genes undergo transformations throughout tumor development, contributing to the aggressiveness of cancer. This research topic focuses on these genes' relationship with cancer progression and their potential as diagnostic markers and treatment targets. Special attention is given to genes like GLUT1, G6PD, TKTL1, PGI/AMF, ACLY, ACC1, FAS, RRM1, RRM2, and TYMS. Their overexpression in tumors and active role in cancer progression offer potential cancer therapy opportunities. The collection also validates their use in cancer diagnoses using a gene microarray database.
While cancer is not only regarded as a disease of pathological cells but also as one of immune hypofunction. Therefore, the application of the gene immunotherapy plays an important role in tumor treatment as well. This therapy integrating transgene delivery or modulating fund expression to directly modulate immune responses in vivo to treat cancer. The heterogeneous and patient-specific nature of cancer further underscores the need for personalized cellular therapies.
Areas to be covered in this Research topic may include but are not limited to:
• Metabolic Changes in Cancer Cells: We welcome research on the pivotal physiological shifts caused by metabolic alterations in cancer cells, including how these changes affect tumor growth and interaction.
• Genetic Role in Tumor Development: We invite studies on transformations in key genes during tumor growth, focusing on their overexpression and active role in cancer progression.
• Genes as Diagnostic and Treatment Aids: Submissions should explore the potential of genes as diagnostic markers or treatment targets, including the development and efficacy of gene-based therapies.
• Gene Immunotherapy & Personalized Treatments: We seek contributions on personalized gene immunotherapies, focusing on in vivo strategies to modulate immune responses, bearing in mind patient-specific tumor characteristics.
Keywords: Gene-Related Metabolic, Cancer therapy, Tumor metabolism, Gene immunotherapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
