Mitochondrial metabolism, often referred to as the "powerhouse of the cell," is crucial for energy production and regulating various cellular processes, including tumorigenesis and immune responses. Recent studies have highlighted the dual role of mitochondria in cancer, where they support tumor growth and simultaneously influence immune cell function. Cancer cells can manipulate mitochondrial metabolism to suppress anti-tumor immune responses, either by outcompeting immune cells for nutrients or by altering the metabolic environment to reduce immune cell efficacy. Despite advances in immunotherapy, response rates remain suboptimal, partly due to these metabolic interactions. Current research has begun to unravel the complex interplay between mitochondrial function and immune cell activity, yet significant gaps remain in understanding how these processes can be modulated to enhance antitumor immunity. Addressing these gaps could lead to more effective therapeutic strategies that leverage mitochondrial metabolism to boost immune responses against tumors.
This research topic aims to investigate the intricate relationship between mitochondrial metabolism and tumor immunity, with the ultimate goal of developing therapies that target mitochondrial functions to restore and enhance antitumor immune activity. Key objectives include identifying specific mitochondrial functions that influence the tumor immune microenvironment, determining which immune cell populations are affected by mitochondrial dysfunction, and understanding how these changes impact immune resistance and antitumor responses.
To gather further insights into the relationship between mitochondrial function and antitumor immunity, we welcome articles addressing, but not limited to, the following themes:
- The impact of mitochondrial metabolism on the tumor immune microenvironment.
- Identification of immune cell populations affected by mitochondrial dysfunction.
- Mechanisms by which mitochondrial metabolism reprogramming influences antitumor immune responses.
- Strategies to modulate mitochondrial functions to enhance immunotherapy efficacy.
- The role of mitochondrial dynamics in immune cell function and tumor resistance.
Keywords:
mitochondrial metabolism, tumor immunity, tumor microenvironment, antitumor response, immunosurveillance
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Mitochondrial metabolism, often referred to as the "powerhouse of the cell," is crucial for energy production and regulating various cellular processes, including tumorigenesis and immune responses. Recent studies have highlighted the dual role of mitochondria in cancer, where they support tumor growth and simultaneously influence immune cell function. Cancer cells can manipulate mitochondrial metabolism to suppress anti-tumor immune responses, either by outcompeting immune cells for nutrients or by altering the metabolic environment to reduce immune cell efficacy. Despite advances in immunotherapy, response rates remain suboptimal, partly due to these metabolic interactions. Current research has begun to unravel the complex interplay between mitochondrial function and immune cell activity, yet significant gaps remain in understanding how these processes can be modulated to enhance antitumor immunity. Addressing these gaps could lead to more effective therapeutic strategies that leverage mitochondrial metabolism to boost immune responses against tumors.
This research topic aims to investigate the intricate relationship between mitochondrial metabolism and tumor immunity, with the ultimate goal of developing therapies that target mitochondrial functions to restore and enhance antitumor immune activity. Key objectives include identifying specific mitochondrial functions that influence the tumor immune microenvironment, determining which immune cell populations are affected by mitochondrial dysfunction, and understanding how these changes impact immune resistance and antitumor responses.
To gather further insights into the relationship between mitochondrial function and antitumor immunity, we welcome articles addressing, but not limited to, the following themes:
- The impact of mitochondrial metabolism on the tumor immune microenvironment.
- Identification of immune cell populations affected by mitochondrial dysfunction.
- Mechanisms by which mitochondrial metabolism reprogramming influences antitumor immune responses.
- Strategies to modulate mitochondrial functions to enhance immunotherapy efficacy.
- The role of mitochondrial dynamics in immune cell function and tumor resistance.
Keywords:
mitochondrial metabolism, tumor immunity, tumor microenvironment, antitumor response, immunosurveillance
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.