About this Research Topic

Background

Cancer is one of the leading causes of death globally, and although there is accumulating knowledge about the mechanisms of cancer development and progression, the cancer burden continues to escalate. This greatly impacts the patients, their families, communities, and health systems.

In some instances, cancer can be prevented. If identified early, it is more likely to respond to first-line treatments like surgery, radiotherapy, hormonal treatments, and more recent targeted biological therapies and immunotherapies.

However, some cancers may develop resistance to therapies and, when diagnosed in advanced stages or at relapse, current therapies may be largely ineffective. Therefore, there is a need to better understand cancer and unveil new targets and approaches for treating it more effectively. In this context, immune evasion and altered cellular metabolism have emerged as hallmarks of cancer and hot topics in cancer research.

Unlike conventional cancer therapies, novel approaches that promise to alleviate the current cancer burden are emerging. New discoveries unveiled important targets for therapy translating to clinical practice namely immunotherapies, which unfortunately are ineffective in several types of cancer and patients. Recently, metabolism shifts have been increasingly recognized as a target to improve cancer responses to chemotherapy and immunotherapy.

This Research Topic aims to highlight the most recent advances in the field of cancer therapy, focusing on new approaches that go beyond traditional ones in the treatment of any type of cancer. Main themes include, but are not limited to:

• Tumor microenvironment and metabolic modulation
• Novel targets for immunotherapy

These approaches may include drug repurposing and advanced delivery strategies, among others, that will allow to advance precision medicine.

In this Research Topic we welcome submissions such as Brief Research Report, Case Report, Clinical Trial, Mini Review, Review, Original Research, and Systematic Review. Our objective is to produce a high-quality article collection covering new promising discoveries and innovative approaches, either at the pre-clinical or clinical levels.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Advanced Delivery Systems, Cancer Metabolism, Cancer Therapy, Immunotherapy, Innovation, Targeted Therapy, Personalized Medicine, Drug Repurposing

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Frequently asked questions

• What is a Research Topic?

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  You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

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  Find out more about our Research Topics

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