About this Research Topic
In humans, nuclear receptors are a family of 48 transcription factors that regulate various gene networks involved in metabolism, inflammation, and circadian rhythm. Due to these fascinating functions, they are widely accepted as therapeutic targets for a range of diseases, including metabolic disorders, inflammatory diseases, and cancers. Various drugs targeting nuclear receptors have been developed for the treatment of these conditions. Traditional drug development strategies focus on ligands, including agonists and antagonists, to target nuclear receptors. Recently, innovative approaches such as epigenetic modifications and PROTACs (Proteolysis Targeting Chimeras) have been proposed, highlighting the dynamic nature of this research field.
The primary aim of this Research Topic is to reflect the current status and recent progress in drug development strategies targeting nuclear receptors for metabolic diseases. Given the essential role that nuclear receptors play as drug targets, there is a significant push toward developing effective therapies. However, challenges such as limited clinical efficacy and potential side effects of drug candidates remain. This collection seeks to address these obstacles by showcasing novel strategies and breakthroughs in the field.
We invite contributions that focus on a broad range of topics related to nuclear receptors, particularly in the context of drug development. The scope of this research topic includes but is not limited to:
• Discovery or development of novel ligands targeting nuclear receptors: This includes the discovery of agonists or antagonists from natural products or endogenous metabolites and the development of ligands with novel structures targeting nuclear receptors.
• Novel strategies targeting nuclear receptors: This encompasses dual agonists, PROTACs, and other innovative approaches.
• New functions and mechanisms of nuclear receptors in metabolic diseases: Research uncovering previously unknown roles and regulatory mechanisms of nuclear receptors.
• Non-genomic functions of nuclear receptors: Studies on how these functions contribute to metabolic diseases.
• Mechanisms underlying the limited transcriptional activity and functions of nuclear receptors: Insight into why certain nuclear receptors exhibit restricted activity and how this affects their therapeutic potential.
• Clinical trials: Reports on candidates targeting nuclear receptors, detailing their efficacy, safety, and outcomes.
We welcome research articles, review articles, and short communications on these topics. Research articles may include studies on the structure of nuclear receptors, the development of novel ligands, the exploration of nuclear receptor functions, and clinical trial results. Reviews may cover summaries and outlooks on drug discovery and development, detailed discussions of the functions and regulation of nuclear receptors, and timely commentaries on significant reports in the field.
The primary aim of this Research Topic is to reflect the current status and recent progress in drug development strategies targeting nuclear receptors for metabolic diseases. Given the essential role that nuclear receptors play as drug targets, there is a significant push toward developing effective therapies. However, challenges such as limited clinical efficacy and potential side effects of drug candidates remain. This collection seeks to address these obstacles by showcasing novel strategies and breakthroughs in the field.
We invite contributions that focus on a broad range of topics related to nuclear receptors, particularly in the context of drug development. The scope of this research topic includes but is not limited to:
• Discovery or development of novel ligands targeting nuclear receptors: This includes the discovery of agonists or antagonists from natural products or endogenous metabolites and the development of ligands with novel structures targeting nuclear receptors.
• Novel strategies targeting nuclear receptors: This encompasses dual agonists, PROTACs, and other innovative approaches.
• New functions and mechanisms of nuclear receptors in metabolic diseases: Research uncovering previously unknown roles and regulatory mechanisms of nuclear receptors.
• Non-genomic functions of nuclear receptors: Studies on how these functions contribute to metabolic diseases.
• Mechanisms underlying the limited transcriptional activity and functions of nuclear receptors: Insight into why certain nuclear receptors exhibit restricted activity and how this affects their therapeutic potential.
• Clinical trials: Reports on candidates targeting nuclear receptors, detailing their efficacy, safety, and outcomes.
We welcome research articles, review articles, and short communications on these topics. Research articles may include studies on the structure of nuclear receptors, the development of novel ligands, the exploration of nuclear receptor functions, and clinical trial results. Reviews may cover summaries and outlooks on drug discovery and development, detailed discussions of the functions and regulation of nuclear receptors, and timely commentaries on significant reports in the field.
Keywords: Nuclear receptors, regulation, drug development
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
