About this Research Topic
An increasing number of individuals are succumbing to cancer due to issues ranging from food safety and environmental degradation to immense work pressure. It has thus become imperative to develop novel compounds that can mitigate humans' cancer risk, particularly given the problem of drug resistance. Both small-molecule compounds and polysaccharides have shown promise in inhibiting tumor cells, yet their precise anti-cancer mechanisms remain largely unknown.
Drug lead compounds can induce apoptosis to suppress tumor cells. Elucidating the anti-cancer molecular mechanisms, including the involved signalling pathways and drug target identification, could spur the development of new drug lead compounds and consequently advance the biomedical industry.
With the progress made in targeted technologies such as antibody-drug conjugates (ADCs), small-molecule drug lead compounds and polysaccharides (especially those derived from macrofungi) are gaining prominence in tumor prevention and treatment efforts. This is largely due to their superior efficacy and minimized side effects. They can restrict tumor cell growth through various cellular biochemical pathways, including apoptosis signal pathways (e.g., Bcl-2/Bax/Caspase-3 pathway, Akt pathway), prevention of EGF-induced cancer cell metastasis, inhibition of mitogen activation, altering tumor cellular microenvironments, and modulating immune cell growth and activity through T-cell reprogramming. Hence, the exploration and elucidation of small-molecule drug lead compounds and polysaccharide's anti-cancer mechanisms are essential for the development of clinical anti-cancer drugs.
We welcome submissions that cover the following subjects:
• Mechanisms of tumor cell apoptosis induced by small molecules
• In vivo tumor inhibition mechanisms using various compounds in mice
• The inhibition of tumor cells through polysaccharides and the mechanisms behind this
• In vivo tumor inhibition by polysaccharides in mice and the mechanisms behind this
• The inhibitory effects of small molecules and polysaccharides on tumors by altering the tumor's microenvironment
Drug lead compounds can induce apoptosis to suppress tumor cells. Elucidating the anti-cancer molecular mechanisms, including the involved signalling pathways and drug target identification, could spur the development of new drug lead compounds and consequently advance the biomedical industry.
With the progress made in targeted technologies such as antibody-drug conjugates (ADCs), small-molecule drug lead compounds and polysaccharides (especially those derived from macrofungi) are gaining prominence in tumor prevention and treatment efforts. This is largely due to their superior efficacy and minimized side effects. They can restrict tumor cell growth through various cellular biochemical pathways, including apoptosis signal pathways (e.g., Bcl-2/Bax/Caspase-3 pathway, Akt pathway), prevention of EGF-induced cancer cell metastasis, inhibition of mitogen activation, altering tumor cellular microenvironments, and modulating immune cell growth and activity through T-cell reprogramming. Hence, the exploration and elucidation of small-molecule drug lead compounds and polysaccharide's anti-cancer mechanisms are essential for the development of clinical anti-cancer drugs.
We welcome submissions that cover the following subjects:
• Mechanisms of tumor cell apoptosis induced by small molecules
• In vivo tumor inhibition mechanisms using various compounds in mice
• The inhibition of tumor cells through polysaccharides and the mechanisms behind this
• In vivo tumor inhibition by polysaccharides in mice and the mechanisms behind this
• The inhibitory effects of small molecules and polysaccharides on tumors by altering the tumor's microenvironment
Keywords: Drug leading compounds, Polysaccharide, Apoptosis, Tumorgenesis, Molecular mechanism
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
