About this Research Topic
Extracellular vesicles (EVs) are small vesicular structures that are released from cells into the extracellular environment. They contain biomolecules such as proteins, nucleic acids, and lipids, which can transmit information between cells, regulate signal transduction, and participate in biological processes such as intercellular communication. In tumors, the number and composition of extracellular vesicles change, which may be closely associated with the onset and progression of tumors. Therefore, the development and utilization of extracellular vesicles for tumor gene therapy has become one of the hotspots of current research.
Through genetic engineering technologies to change the content or nature of biomolecules in extracellular vesicles, cancer-related signaling pathways can be regulated and precision treatment can be achieved. Research in this field is not only expected to bring new breakthroughs in cancer treatment but also promote the development of the field of gene therapy and provide new possibilities for future personalized medicine. Although some progress has been made in laboratory and clinical trials to develop gene therapy for extracellular vesicles, several challenges remain, necessitating further studies.
The following are some critical issues and themes that need to be addressed:
1. Precise regulation of extracellular vesicle generation and release to improve clinical therapeutic efficacy and reduce side effects.
2. Selection of appropriate vectors and delivery routes for gene therapy via extracellular vesicles to ensure both efficacy and safety.
3. Utilization of the biomolecules within extracellular vesicles to design more intelligent gene therapy strategies for personalized treatments.
4. Application of genomics and artificial intelligence to predict cancer prognosis.
To this end, we particularly encourage the submission of original research articles and papers detailing the new methodology. Through continuous in-depth research and technological innovation, it is believed that gene therapy with extracellular vesicles will bring new breakthroughs in the treatment of diseases.
Through genetic engineering technologies to change the content or nature of biomolecules in extracellular vesicles, cancer-related signaling pathways can be regulated and precision treatment can be achieved. Research in this field is not only expected to bring new breakthroughs in cancer treatment but also promote the development of the field of gene therapy and provide new possibilities for future personalized medicine. Although some progress has been made in laboratory and clinical trials to develop gene therapy for extracellular vesicles, several challenges remain, necessitating further studies.
The following are some critical issues and themes that need to be addressed:
1. Precise regulation of extracellular vesicle generation and release to improve clinical therapeutic efficacy and reduce side effects.
2. Selection of appropriate vectors and delivery routes for gene therapy via extracellular vesicles to ensure both efficacy and safety.
3. Utilization of the biomolecules within extracellular vesicles to design more intelligent gene therapy strategies for personalized treatments.
4. Application of genomics and artificial intelligence to predict cancer prognosis.
To this end, we particularly encourage the submission of original research articles and papers detailing the new methodology. Through continuous in-depth research and technological innovation, it is believed that gene therapy with extracellular vesicles will bring new breakthroughs in the treatment of diseases.
Keywords: extracellular vesicles, genetic engineering, tumor microenvironment, cancer treatment, therapeutic target
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