About this Research Topic
The integration of HSCT and CAR-T therapy represents a pioneering approach that could dramatically improve treatment outcomes by combining their complementary mechanisms to address challenges such as the treatment of refractory/relapsed malignancies, novel prophylaxis of GVHD, new myeloablative conditioning, and new therapeutic targets. This Research Topic aims to deepen the understanding of immunological advancements in these therapies, exploring innovative strategies to enhance and integrate them to improve patient outcomes. By bringing together cutting-edge research and clinical insights, this forum seeks to foster innovative approaches that could lead to significant breakthroughs in therapy efficacy and accessibility, spotlighting recent immunological breakthroughs that refine these vital therapies.
In this Research Topic, we welcome submissions of Original Research, Methods, Materials, Protocols, Classifications, Reviews, Mini-reviews, Perspective, and Clinical Trial articles covering recent advances in the following areas:
1) Mechanisms of CAR-T activation, expansion, cytotoxicity, and in vivo persistence.
2) Methods for enhancing the function, accessibility, and druggability of CAR-T cells (e.g., CAR design, T cell function, and crafting manufacturing techniques).
3) Clinical trials of CAR-T cells against diseases, particularly novel indications such as autoimmune diseases and solid tumors.
4) Mechanisms of immune tolerance and alloimmunity.
5) Pathophysiology of acute and chronic graft-versus-host disease (GvHD) after allogeneic hematopoietic stem cell transplantation (Allo-HSCT).
6) Clinical trials focused on prevention and treatment of acute and chronic GvHD.
Keywords: Hematopoietic stem cell transplantation (HSCT), CAR-T cell therapy, Hematological Therapies, Graft-Versus-Host Disease (GvHD), Tumor Immunology
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.