Plant-derived formulations and phytochemicals have gained significant attention for treating many malignancies, including cervical cancer, owned by a growing body of evidence supporting their effectiveness. In addition, they have demonstrated considerable ability to regulate the activity of key signalling pathways linked to the advancement of cervical cancer. The anti-cancer efficacy of vinblastine, doxorubicin, camptothecin, and paclitaxel has increased with the use of plant-based chemotherapeutic drugs. Owing to expanded research, the mechanisms of abnormal signal transduction pathways in cervical cancer and their effects on tumour development, cell death, and cancer spread have been increasingly uncovered. The exploration of plant-derived molecules that can control signal transduction has recently been widely recognized in the field of biomedicine. Plant metabolites exhibit efficacy against multiple signalling pathways, including those involved in cell death (apoptosis and autophagy) and embryonic development (Notch, Wnt, and Hh pathways). The historical documentation of natural products is robust; however, it is imperative to examine the present-day significance of natural products in the identification and advancement of cervical cancer medications to ascertain the potential of natural products to serve as crucial sources of future therapeutic agents. Several anti-cancer medications designed to target specific molecules have proven ineffective, highlighting the need to explore natural compounds that possess several targets to obtain improved results. Natural products have the potential to serve as promising new substances for cervical cancer treatment, making them a crucial focus of research.
This Research Topic aims to identify novel natural compounds from plants and their molecular mode of action via targeting aberrant cell signalling pathways in cervical cancer progression. Altogether, the experimental data and evidence presented in this collection will help scientists and researchers understand the assorted beneficial effects of the numerous classes of natural products for developing new and safe drugs for possible cervical cancer therapy.
Submissions must be related to cervical cancer, including, but not limited to, the following themes are welcome:
• The mechanisms of cervical cancer's abnormal signal transduction pathways and their effects on carcinogenesis, apoptosis, and metastasis.
• Role of plant phytochemicals in the cell signalling modulations in cervical cancer.
• Therapeutic potential of plant phytochemicals by targeting multiple oncogenic signalling pathways in cervical cancer
• Natural products as EMT modulators used in cervical cancer
• Potential adjuvant therapies of plant products with chemotherapeutic drugs in cervical cancer therapy.
• Plant products nanoformulations as cell signalling modulators in cervical cancer.
Original Research, Reviews, Mini Reviews, and Perspective articles on the abovementioned themes are welcome.
Valid compounds of natural origin in the Pharmacology of Anti-Cancer Drugs section refer to biologically active substances from natural sources like plants, marine organisms, and microorganisms.
Manuscripts dealing with plant extracts or other natural substances/compounds must describe the composition and stability of the study material in sufficient detail. In particular, for extracts, chromatograms with characterization of the dominant compound(s) are requested. The level of purity must be proven and included.
Keywords:
Natural compounds, cancer, cell signaling pathways, apoptosis, cancer therapy
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Plant-derived formulations and phytochemicals have gained significant attention for treating many malignancies, including cervical cancer, owned by a growing body of evidence supporting their effectiveness. In addition, they have demonstrated considerable ability to regulate the activity of key signalling pathways linked to the advancement of cervical cancer. The anti-cancer efficacy of vinblastine, doxorubicin, camptothecin, and paclitaxel has increased with the use of plant-based chemotherapeutic drugs. Owing to expanded research, the mechanisms of abnormal signal transduction pathways in cervical cancer and their effects on tumour development, cell death, and cancer spread have been increasingly uncovered. The exploration of plant-derived molecules that can control signal transduction has recently been widely recognized in the field of biomedicine. Plant metabolites exhibit efficacy against multiple signalling pathways, including those involved in cell death (apoptosis and autophagy) and embryonic development (Notch, Wnt, and Hh pathways). The historical documentation of natural products is robust; however, it is imperative to examine the present-day significance of natural products in the identification and advancement of cervical cancer medications to ascertain the potential of natural products to serve as crucial sources of future therapeutic agents. Several anti-cancer medications designed to target specific molecules have proven ineffective, highlighting the need to explore natural compounds that possess several targets to obtain improved results. Natural products have the potential to serve as promising new substances for cervical cancer treatment, making them a crucial focus of research.
This Research Topic aims to identify novel natural compounds from plants and their molecular mode of action via targeting aberrant cell signalling pathways in cervical cancer progression. Altogether, the experimental data and evidence presented in this collection will help scientists and researchers understand the assorted beneficial effects of the numerous classes of natural products for developing new and safe drugs for possible cervical cancer therapy.
Submissions must be related to cervical cancer, including, but not limited to, the following themes are welcome:
• The mechanisms of cervical cancer's abnormal signal transduction pathways and their effects on carcinogenesis, apoptosis, and metastasis.
• Role of plant phytochemicals in the cell signalling modulations in cervical cancer.
• Therapeutic potential of plant phytochemicals by targeting multiple oncogenic signalling pathways in cervical cancer
• Natural products as EMT modulators used in cervical cancer
• Potential adjuvant therapies of plant products with chemotherapeutic drugs in cervical cancer therapy.
• Plant products nanoformulations as cell signalling modulators in cervical cancer.
Original Research, Reviews, Mini Reviews, and Perspective articles on the abovementioned themes are welcome.
Valid compounds of natural origin in the Pharmacology of Anti-Cancer Drugs section refer to biologically active substances from natural sources like plants, marine organisms, and microorganisms.
Manuscripts dealing with plant extracts or other natural substances/compounds must describe the composition and stability of the study material in sufficient detail. In particular, for extracts, chromatograms with characterization of the dominant compound(s) are requested. The level of purity must be proven and included.
Keywords:
Natural compounds, cancer, cell signaling pathways, apoptosis, cancer therapy
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.