Liver Diseases and Their Impact on Drug Metabolism

The metabolism and detoxification of xenobiotic compounds, including drugs, takes place mainly in the liver and, therefore, liver diseases may negatively affect these processes. This Research Topic aims to highlight recent advances in research on alterations in drug metabolism and detoxification pathways under various pathological states, focusing mainly but not only on metabolic dysfunction-associated steatotic liver disease (MASLD). Further, this issue also covers the advances in the treatment of hepatic disorders and their effect on drug metabolism. A wide range of studies addressing these topics are welcome, including both original research and review articles looking at, but not limited to, the following:

• Investigation of biochemical/pharmacological underpinnings of alterations in drug metabolism associated with hepatic diseases.

• Implementation of modern research methods (e.g. omics) to discover underlying mechanisms of alterations in drug metabolism under pathological states.

• Using animal models mimicking pathological states to search for suitable biomarkers of hepatic disorders and new treatment options.

• Understanding the disturbances in transcriptional, post-transcriptional and epigenetic regulations of detoxification pathways under pathological states.

Keywords: Liver Diseases, Drug Metabolism, Xenobiotic Compounds, Omics, Biomarkers, Detoxification Pathways

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.